The adaptability of regulatory T cells and Foxp3
The adaptability of regulatory T cells and Foxp3
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调节性T细胞和Foxp3的适应性
DOI：
10.1093/intimm/dxab045
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发表时间：
2021
期刊：
影响因子：
4.4
通讯作者：
Hori S and Murakami R
中科院分区：
文献类型：
--
作者：
Matsumoto S;Harada A;Kikuchi A.;Hori S and Murakami R
表达谱系定义转录因子Foxp3的调节性T（Treg）细胞在建立和维持免疫和组织稳态中起关键作用。Foxp3作为一个高度连接的“枢纽”，与许多基因组位点和伴侣蛋白相互作用，在分子网络中协调Treg细胞分化和功能的多个方面。Treg细胞分布于全身，从淋巴组织到大多数非淋巴组织，在那里它们发挥适合于组织和免疫环境的抗炎和保护功能。因此，它们能够通过动态地整合外在线索与内在分子网络来适应多样化和不断变化的环境。在这篇综述中，我们讨论了最近的进展，我们了解的细胞内在和外在机制的适应性Treg细胞，我们提出了一个至关重要的作用，Foxp3为中心的分子网络，它在一个多模态和适应性的方式来响应环境信号。
Regulatory T (Treg) cells that express the lineage-defining transcription factor Foxp3 play a pivotal role in establishing and maintaining immune and tissue homeostasis. Foxp3 serves as a highly connected ‘hub’, interacting with numerous genomic sites and partner proteins, in the molecular network that orchestrates multiple facets of Treg cell differentiation and function. Treg cells are distributed throughout the body from lymphoid tissues to most non-lymphoid tissues, where they exert anti-inflammatory and protective functions appropriate for the tissue and immune environment. They are thus capable of adapting to diverse and changing environments by dynamically integrating extrinsic cues with the intrinsic molecular network. In this review, we discuss recent advances in our understanding of the cell-intrinsic and -extrinsic mechanisms underlying the adaptability of Treg cells and we propose a crucial role for the Foxp3-centered molecular network, which operates in a multimodal and adaptive manner in response to environmental signals.