Interaction between gut microbiome and cardiovascular disease
Interaction between gut microbiome and cardiovascular disease
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DOI：
10.1016/j.lfs.2018.10.063
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
张湘瑜
中科院分区：
文献类型：
--
作者：
彭洁婷;肖迅;胡敏;张湘瑜
Traditional cardiovascular risk factors do not underlie all incidence of cardiovascular disease. In recent years, accumulating evidence has demonstrated that gut microbiota and its metabolites also play a pivotal role in the onset and development of cardiovascular disease, including atherosclerosis, hypertension, heart failure, atrial fibrillation and myocardial fibrosis. Trillions of bacteria indwell the gastrointestinal tract and metabolize nutrients into trimethylamine-N-oxide, short-chain fatty acids and so on. Targeting these microorganisms and relevant metabolic pathways has beneficial effects in cardiovascular disease. This review will summarize the role of gut microbiota and its metabolites, mainly trimethylamine-N-oxide, in the pathogenesis of cardiovascular diseases, and discuss the possible mechanisms that drive cardiovascular diseases and highlight potential therapies in this field
