Porcine reproductive and respiratory syndrome virus: Description of persistence in individual pigs upon experimental infection
Porcine reproductive and respiratory syndrome virus: Description of persistence in individual pigs upon experimental infection
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DOI：
10.1128/jvi.74.22.10834-10837.2000
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发表时间：
2000-11-01
影响因子：
5.4
通讯作者：
Osorio, FA
中科院分区：
文献类型：
--
作者：
Allende, R;Laegreid, WW;Osorio, FA
我们研究了猪繁殖与呼吸综合征病毒（PRRSV）的持久性在个别实验感染的猪，在长达150天的感染后（dpi）。这项研究的结果表明，PRRSV的持久性涉及连续的病毒复制，但它不是一个真正的稳态持续感染。病毒最终清除身体，似乎在150 dpi或之后不久在大多数动物中完成。虽然在包膜糖蛋白和M蛋白基因中也观察到一些一致的突变，但在持久性PRRSV基因组的几个区域中观察到高遗传稳定性。
We studied the persistence of porcine reproductive and respiratory syndrome virus (PRRSV) in individual experimentally infected pigs, during a period of up to 150 days postinfection (dpi). The results of this study suggest that the persistence of PRRSV involves continuous viral replication but that it is not a true steady-state persistent infection. The virus eventually clears the body and seems to do it in most of the animals by 150 dpi or shortly thereafter. High genetic stability was seen for several regions of the persistent PRRSV's genome, although some consistent mutations in the genes of envelope glycoproteins and M protein were also observed.