Transcriptional regulation of bone formation.
Transcriptional regulation of bone formation.
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DOI：
10.2741/s138
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发表时间：
2011-01-01
期刊：
影响因子：
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通讯作者：
Kim, Jung-Eun
中科院分区：
文献类型：
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作者：
Baek, Wook-Young;Kim, Jung-Eun
脊椎动物的骨形成依赖于软骨细胞和成骨细胞的增殖和分化，软骨细胞和成骨细胞来源于间充质前体细胞，是骨骼发育所必需的。这一过程依赖于许多在骨细胞增殖和分化中起作用的转录因子基因。多年来，在体内和/或体外分子和遗传学研究中发现了多种对骨骼形成起重要作用的转录因子。在骨形成的调控中，也建立了这些因子的信号通路。Sox9、Runx2、Osterix等主要转录因子在软骨细胞或成骨细胞中，甚至在两种细胞中都有活性，是软骨细胞和/或成骨细胞分化不可缺少的。在这里，这些基因对骨形成的转录调控将在体内小鼠模型的基础上进行综述。
Bone formation in vertebrates depends on the proliferation and differentiation of chondrocytes and osteoblasts, which are derived from a mesenchymal precursor cells and are required for skeletal development. This process relies on many transcription factor genes that have functions in bone cell proliferation and differentiation. Over the years, various transcription factors that play essential roles for skeletal formation have been identified in in vivo and/or in vitro molecular and genetic studies. In regulation of bone formation, signaling pathways with these factors have also been established. Major transcription factors including Sox9, Runx2, and Osterix, which are active in chondrocytes or osteoblasts or even in both cells, are indispensable for chondrocyte and/or osteoblast differentiation. Here, the transcriptional regulation of these genes for bone formation will be reviewed on the basis of in vivo mouse models.