Alcohol consumption and internalising disorders in young adults of ALSPAC: a population-based study.
Alcohol consumption and internalising disorders in young adults of ALSPAC: a population-based study.
复制标题
DOI：
10.1136/jech-2020-213922
复制
发表时间：
2020-12
影响因子：
6.3
通讯作者：
Heron J
中科院分区：
文献类型：
--
作者：
Fernandes GS;Lewis G;Hammerton G;Abeysekera K;Mahedy L;Edwards A;Lewis G;Hickman M;Heron J
抑郁症和有害的酒精消费对全球健康负担有重大影响，但在年轻人中，这种关系研究不足，相互矛盾。这项研究的目的是确定基于性别的患病率和内化障碍如抑郁症和酒精使用障碍之间的关联。使用雅芳父母和儿童纵向研究，我们评估了24岁时（n=3572）诊断为广泛性焦虑症（GAD）、抑郁症和基于恐惧的焦虑症（FBA）的国际疾病分类第十次修订版的性别特异性患病率。我们使用酒精使用障碍识别测试消费5+阈值和精神疾病诊断和统计手册定义的酒精依赖标准来检查内化障碍和酒精消费之间的关联。女性报告的GAD（11.6% vs 6.5%）、抑郁（13.4% vs 6.9%）和FBA（1.3% vs 0.5%）高于男性（p<0.001）。在调整性别和社会经济地位后，有害饮酒与抑郁症的患病率较高相关（OR 1.8，95% CI 1.3至2.4，p<0.001），焦虑（OR 1.4，95% CI 1.0至2.0，p<0.001）和FBA（OR 2.4，95% CI 1.04至5.56，p=0.009）与低风险饮酒者相比。相反，与低风险饮酒者相比，危险饮酒与GAD（OR 0.69，95%CI 0.54至0.88）和抑郁症（OR 0.68，95%CI 0.54至0.86）的患病率较低相关。在英国，酗酒的年轻人更有可能患抑郁症和其他内化障碍。进一步的研究应该测试年轻人的酒精消费和心理健康之间是否存在J形关系，以及这种关系是否在整个生命过程中有所不同。
Depression and harmful alcohol consumption contribute significantly to the global health burden, but in young adults, this relationship is under-researched and conflicted. The aim of this study was to determine the sex-based prevalence and the association between internalising disorders such as depression and alcohol use disorders. Using the Avon Longitudinal Study of Parents and Children, we assessed the sex-specific prevalence of International Classification of Diseases, Tenth Revision diagnosed generalised anxiety disorder (GAD), depression and fear-based anxieties (FBA) at 24 years (n=3572). We examined the association between internalising disorders and alcohol consumption using the Alcohol Use Disorder Identification Test for Consumption 5+ threshold and Diagnostic and Statistical Manual on Mental Disorders defined criteria for alcohol dependence. Women reported more GAD (11.6% vs 6.5%), depression (13.4% vs 6.9%) and FBA (1.3% vs 0.5%) than men (p<0.001). Harmful drinking, after adjustment for sex and socioeconomic status, was associated witha higher prevalence of depression (OR 1.8, 95% CI 1.3 to 2.4, p<0.001), anxiety (OR 1.4, 95% CI 1.0 to 2.0, p<0.001) and FBA (OR 2.4, 95% CI 1.04 to 5.56, p=0.009) compared with lower-risk drinkers. In contrast, hazardous drinking was associated with a lower prevalence of GAD (OR 0.69, 95% CI 0.54 to 0.88) and depression (OR 0.68, 95% CI 0.54 to 0.86) compared with lower-risk drinkers. Young adults in the UK who drink harmfully are more likely to have depression and other internalising disorders. Further research should test whether there is a J-shaped relationship between alcohol consumption and mental health in young people and whether this varies across the life course.
登录
查看更多内容
影响因子：
7.6
作者：
Dube, S. R.;Miller, J. W.;Anda, R. F.
通讯作者：
Anda, R. F.
影响因子：
4.2
作者：
Degenhardt, L;Hall, W;Lynskey, M
通讯作者：
Lynskey, M
影响因子：
2.8
作者：
Frojd, Sari;Ranta, Klaus;Marttunen, Mauri
通讯作者：
Marttunen, Mauri
影响因子：
6.6
作者：
Bolton, James M.;Robinson, Jennifer;Sareen, Jitender
通讯作者：
Sareen, Jitender
影响因子：
6.9
作者：
Head J;Stansfeld SA;Ebmeier KP;Geddes JR;Allan CL;Lewis G;Kivimäki M
通讯作者：
Kivimäki M