DESFERRIOXAMINE AMELIORATES RETINAL PHOTIC INJURY IN ALBINO-RATS
DESFERRIOXAMINE AMELIORATES RETINAL PHOTIC INJURY IN ALBINO-RATS
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DOI：
10.3109/02713689109001741
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发表时间：
1991-02-01
影响因子：
2
通讯作者：
TSO, MOM
中科院分区：
文献类型：
--
作者：
LI, ZL;LAM, S;TSO, MOM
白化病大鼠在暴露于强荧光灯前腹腔注射去铁胺。 视网膜的形态测量和形态学研究表明，与对照组大鼠相比，去铁胺治疗组大鼠的感光细胞核和视网膜下巨噬细胞的保存更好。 研究结果提示，铁和羟基自由基可能是视网膜光损伤的重要介质。
Albino rats were given intraperitoneal desferrioxamine before exposure to intense fluorescent light. Morphometric and morphologic studies of the retina indicated that there was better preservation of photoreceptor nuclei and fewer subretinal macrophages in rats treated with desferrioxamine than in the control rats. The results of the study imply that iron and hydroxyl radicals may be important mediators in photic retinal injury.