Increased expression of SRPK1 (serine/arginine-rich protein-specific kinase 1) is associated with progression and unfavorable prognosis in cervical squamous cell carcinoma.
Increased expression of SRPK1 (serine/arginine-rich protein-specific kinase 1) is associated with progression and unfavorable prognosis in cervical squamous cell carcinoma.
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SRPK1（富含丝氨酸/精氨酸的蛋白特异性激酶 1）表达增加与宫颈鳞状细胞癌的进展和不良预后相关
DOI：
10.1080/21655979.2022.2034705
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发表时间：
2022-03
期刊：
影响因子：
4.9
通讯作者：
Hou Y
中科院分区：
文献类型：
--
作者：
Dong Z;Chang X;Xie L;Wang Y;Hou Y
摘要以往的研究表明，SRPK1(富含丝氨酸/精氨酸的蛋白特异性激酶1)参与了肿瘤的发生，并与不良预后密切相关。然而，其在宫颈鳞状细胞癌(CESC)中的表达模式尚不清楚。在本研究中，我们初步探讨了SRPK1在人类CESC中的临床意义和功能。利用TCGA数据库对CESC组织中SRPK1mRNA的表达进行数据挖掘和分析，结果表明SRPK1mRNA在CESC组织中显著上调。采用免疫组织化学方法检测了122例CESC组织中SRPK1蛋白的表达，发现SRPK1蛋白在CESC组织中的表达丰度较高，其异常上调与患者的生存状况明显相关。COX比例风险回归分析进一步证实了SRPK1是CESC的独立预后因素。细胞实验证实，SRPK1可能通过促进CESC的增殖、迁移和侵袭而发挥作用。结论：SRPK1的异常上调与CESC的进展和预后不良密切相关，可作为CESC的一个新的预后生物标志物和治疗靶点。
ABSTRACT Previous studies suggest that SRPK1 (serine/arginine-rich protein-specific kinase 1) is involved in tumorigenesis and closely related to unfavorable outcomes. However, its expression pattern in cervical squamous cell carcinoma (CESC) remains uncovered. In this study, we initially investigated the clinical significance and function of SRPK1 in human CESC. Data mining and analysis on SRPK1 mRNA expression in CESC samples were conducted using TCGA database, which indicated that SRPK1 mRNA was significantly upregulated in CESC samples. Protein expression of SRPK1 was tested by immunohistochemistry in a retrospective cohort (n = 122), revealing a higher SRPK1 protein abundance in CESC specimens whose aberrant up-regulation was obviously related to worse survival. Cox proportional hazards regression analysis further confirmed the role of SRPK1 as an independent prognostic factor of CESC. Cellular experiments validated that SRPK1 may function through enhancing CESC proliferation, migration, and invasion. In conclusion, aberrant up-regulation of SRPK1 is remarkably related to progression and unfavorable prognosis of CESC, which can serve as a novel prognostic biomarker and therapeutic target for CESC.
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