Effects of estradiol on food intake and meal patterns for diets that differ in flavor and fat content
Effects of estradiol on food intake and meal patterns for diets that differ in flavor and fat content
复制标题
DOI：
10.1016/j.physbeh.2009.10.009
复制
发表时间：
2010-01-01
影响因子：
2.9
通讯作者：
Clough, Shannon J.
中科院分区：
文献类型：
--
作者：
Butera, Peter C.;Wojcik, Danielle M.;Clough, Shannon J.
除了众所周知的雌二醇对食物摄入量的抑制作用外，膳食量。和体重，最近的一份报告提出了相反的发现：大剂量的雌二醇可以增加饮食可口的性腺完整的雌性大鼠的食物摄入和体重增加。本实验的目的是通过评价雌二醇影响卵巢切除大鼠进食不同风味和脂肪含量饮食的能力，进一步检验这一假设。给予雌性大鼠苯甲酸雌二醇治疗（5.0或20.0 μ g）或油溶剂的循环方案，并给予标准饲料或具有较高脂肪含量和巧克力风味的饲料。食物摄入。在第一次注射雌二醇或油后三天监测进餐量和进餐次数。与普通饲料相比，在溶媒给药条件下，当动物可获得巧克力/脂肪饲料时，摄食量增加。两种剂量的雌二醇显着降低食物摄入量，膳食量，体重增加时，动物与标准饲料或巧克力/脂肪饮食。这些研究结果表明，雌二醇并不刺激摄入可口的饮食在卵巢切除大鼠，并建议以前的结果表明，雌二醇增强进食和体重增加源于中断的下丘脑-垂体-性腺轴时，完整的女性收到了大剂量的外源性雌二醇。(C)2009爱思唯尔公司All rights reserved.
Apart from the well known inhibitory effects of estradiol on food intake, meal size. and body weight in female rats that have been documented over the past thirty years, a more recent report presents the opposite finding: that a large dose of estradiol can increase food intake and weight gain in gonadally intact female rats presented with a palatable diet. The purpose of the present experiment was to further examine this hypothesis by evaluating the ability of estradiol to influence feeding behavior in ovariectomized rats presented with diets that differ in flavor and fat content. Female rats were given a cyclic regimen of estradiol benzoate treatment (5.0 or 20.0 mu g) or the oil vehicle and were presented with the standard chow diet or a diet with a higher fat content and chocolate flavor. Food intake. meal size, and meal number were monitored three days after the first injection of estradiol or oil. Compared to the chow diet, food intake increased when animals had access to the chocolate/fat diet during the vehicle treatment condition. Both doses of estradiol significantly decreased food intake, meal size, and body weight gain when animals were presented with either the standard chow diet or the chocolate/fat diet. These findings indicate that estradiol does not stimulate the intake of a palatable diet in ovariectomized rats, and suggest that previous results showing that estradiol enhanced eating and weight gain stemmed from a disruption of the hypothalamic-pituitary-gonadal axis when intact females received a large dose of exogenous estradiol. (C) 2009 Elsevier Inc. All rights reserved.