Effects of prenatal alcohol exposure on fine motor coordination and balance: A study of two adult samples
Effects of prenatal alcohol exposure on fine motor coordination and balance: A study of two adult samples
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DOI：
10.1016/j.neuropsychologia.2005.07.016
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发表时间：
2006-01-01
期刊：
影响因子：
2.6
通讯作者：
Barr, HM
中科院分区：
文献类型：
--
作者：
Connor, PD;Sampson, PD;Barr, HM
在两个成年受试者样本中评估运动协调：一个样本（n = 90）包括先前诊断为胎儿酒精谱系障碍（FASD）之一的成年人和比较同龄人，第二个是一项前瞻性纵向研究，研究对象是胎儿时暴露于不同水平酒精的成年人（n = 402）。这项比较分析旨在确定在临床和非临床儿童中观察到的运动效应是否持续到成年，是否有任何个体运动任务显示出产前酒精暴露对整个年龄范围的显著影响，以及成人运动评估是否在疑似FASD的成人诊断策略中发挥任何作用。运动测试包括平衡和单侧，双侧，手指，手和脚的协调。四分之三的FASD受试者表现出运动功能缺陷，超出了对照受试者的范围。患有FASD的成年人平均在所有个人测试中表现更差，包括平衡和精细运动控制。在前瞻性纵向样本中，相对于对照受试者，只有在儿童时期被确定为可能诊断为胎儿酒精谱的受试者在成年后仍在运动任务中处于缺陷状态。因此，先前在儿童中发现的酒精剂量依赖性运动协调效应似乎不会持续到成年，除了那些在童年时期也有其他伴随神经心理效应的高度暴露儿童。(c)2005爱思唯尔有限公司保留所有权利。
Motor coordination was assessed in two samples of adult subjects: one sample (n = 90) included adults previously diagnosed with one of a number of Fetal Alcohol Spectrum Disorders (FASD) and comparison peers, the second was a prospective longitudinal study of adults who were exposed to varying levels of alcohol as fetuses (n = 402). This comparative analysis sought to determine whether motor effects seen in both clinical and nonclinical children persist into adulthood, whether any individual motor tasks show significant effects of prenatal alcohol exposure across the age range, and whether motor assessments of adults have any role in diagnostic strategies for adults suspected of FASD. Motor tests included balance and unilateral, bilateral, finger, hand and foot coordination. Three-quarters of the subjects with FASD demonstrated deficits in motor function outside the range of comparison subjects. Adults with FASD performed more poorly, on average, on all individual tests including balance and fine motor control. In the prospective longitudinal sample, only subjects who had been previously identified in childhood as having a possible diagnosis on the Fetal Alcohol Spectrum were still in deficit as adults on motor tasks, relative to comparison subjects. Thus, the dose-dependent motor coordination effects of alcohol previously found in children do not appear to persist into adulthood, except in those most highly exposed children who also have other accompanying neuropsychological effects in childhood. (c) 2005 Elsevier Ltd. All rights reserved.