Tobacco carcinogen metabolites and DNA adducts as biomarkers in head and neck cancer: potential screening tools and prognostic indicators.
Tobacco carcinogen metabolites and DNA adducts as biomarkers in head and neck cancer: potential screening tools and prognostic indicators.
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DOI：
10.1002/hed.21705
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发表时间：
2012-03
期刊：
影响因子：
--
通讯作者：
Hecht SS
中科院分区：
文献类型：
--
作者：
Khariwala SS;Hatsukami D;Hecht SS
头颈部鳞状细胞癌（HNSCC）是与烟草使用密切相关的许多癌症之一。虽然HNSCC经常出现在烟草使用者中，但许多烟草使用者不会发生癌症;迄今为止，对吸烟者与无HNSCC之间的差异研究甚少。一些吸烟者可能天生更容易患上癌症，这是由于烟草使用模式、致癌物的先天代谢或排泄改变。通过有针对性的戒烟努力和加强监测，确定HNSCC风险最大的吸烟者将有很大的好处。更好地了解烟草致癌物的暴露程度和代谢程度的一种方法是通过使用烟草特有的代谢物。烟草特异性代谢物可以识别剂量，暴露和代谢模式，并可能最终表征发展HNSCC的吸烟者和未发展HNSCC的吸烟者之间的重要差异。
Head and neck squamous cell carcinoma (HNSCC) is one of many cancers that are strongly associated with tobacco use. Whereas HNSCC is often seen in tobacco users, many tobacco users do not develop carcinoma; and the differences between smokers with and without HNSCC are poorly studied to date. Some smokers may be inherently more susceptible to developing carcinoma due to patterns of tobacco use, innate metabolism of carcinogens, or altered excretion. Identifying those smokers at greatest risk for HNSCC would have great benefit through targeted smoking cessation efforts and enhanced surveillance. One approach to better understand the extent of exposure to, and metabolism of, tobacco carcinogens is through the use of tobacco-specific metabolites. Tobacco-specific metabolites can identify patterns of dose, exposure, and metabolism, and perhaps ultimately characterize the important differences between smokers who develop HNSCC and smokers who do not.
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影响因子：
4.1
作者：
Cheng, G;Shi, YL;Hecht, SS
通讯作者：
Hecht, SS
影响因子：
4.1
作者：
Chen, Li;Wang, Mingyao;Hecht, Stephen S.
通讯作者：
Hecht, Stephen S.
DOI：
10.1016/0378-4347(84)80202-9
发表时间：
1984-01-01
期刊：
JOURNAL OF CHROMATOGRAPHY
影响因子：
--
作者：
BELAND, FA;FULLERTON, NF;HEFLICH, RH
通讯作者：
HEFLICH, RH
影响因子：
4.7
作者：
HECHT, SS;HOFFMANN, D
通讯作者：
HOFFMANN, D
影响因子：
10.3
作者：
Fakhry, Carole;Westra, William H.;Gillison, Maura L.
通讯作者：
Gillison, Maura L.