CHOLECYSTOKININ (CCK-8) ELICITS PRANDIAL SLEEP IN RATS
CHOLECYSTOKININ (CCK-8) ELICITS PRANDIAL SLEEP IN RATS
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DOI：
10.1016/0031-9384(83)90002-1
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发表时间：
1983-01-01
影响因子：
2.9
通讯作者：
LORENZ, DN
中科院分区：
文献类型：
--
作者：
MANSBACH, RS;LORENZ, DN
在禁食17h后的第一餐和两餐间歇期间，记录不受束缚的成年大鼠的脑电活动和行为。CCK-8，5、10、20、40和80IDU/kg，ip。给药后10min，小鼠摄食受到抑制，安静行为、同步波睡眠和非同步波睡眠时间延长，并呈剂量依赖关系。80IDU/kg剂量引起的脑电和行为模式与餐后对照组大鼠难以区分。显然，缩胆囊素能引起大鼠对食物的饱足感，而不是疾病。显然，脑电测量可以用来量化餐后饱腹感的状态。
EEG activity and behaviors were recorded in unrestrained adult rats during their 1st meal and intermeal interval following 17 h of food deprivation. Cholecystokinin (CCK-8), in doses of 5, 10, 20, 40 and 80 IDU/kg injected i.p. 10 min after feeding began, suppressed ingestion, elicited and prolonged rest behavior, synchronous wave sleep and desynchronous wave sleep in a dose-related manner. The 80 IDU/kg dose elicited EEG and behavioral patterns indistinguishable from those of the postprandial control rats. Apparently, cholecystokinin elicits satiety for food in rats, not illness. EEG measures evidently can be used to quantify the postprandial state of satiety.