The transcriptional repression of platelet-derived growth factor receptor-13 by the zinc finger transcription factor ZNF24
The transcriptional repression of platelet-derived growth factor receptor-13 by the zinc finger transcription factor ZNF24
复制标题
锌指转录因子 ZNF24 对血小板源性生长因子受体 13 的转录抑制
DOI：
10.1016/j.bbrc.2010.05.110
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发表时间：
2010-06-25
影响因子：
3.1
通讯作者：
Zhang, Junping
中科院分区：
文献类型：
--
作者：
Li, Jianzhong;Chen, Xia;Zhang, Junping
锌指转录因子ZNF 24是一种相对不具有特征的Kruppel样转录因子，对转录具有抑制作用。ZNF 24参与血管内皮生长因子（VEGF）的负调控，可能是一种新的VEGF转录抑制因子。在以前的研究中，我们的分析表明ZNF 24是一种多效性因子，在造血，脑发育和癌症中发挥作用。PDGFR-β的活化与多种细胞功能密切相关，包括基质细胞的募集和肿瘤和血管周围细胞中VEGF的诱导。在这里，ZNF 24的过表达导致PDGFR-β的显著下调，而用小干扰RNA沉默ZNF 24导致PDGFR-β表达增加。ZNF 24的过表达导致PDGFR-β启动子活性的显著降低。这些数据表明，ZNF 24参与PDGFR-β的负调控，并可能代表PDGFR-β转录的新阻遏物。皇冠版权所有（C）2010由爱思唯尔公司出版。All rights reserved.
The zinc finger transcription factor ZNF24 is a relatively uncharacterized Kruppel-like transcription factor, displaying a suppressive effect on the transcription. ZNF24 is involved in negative regulation of vascular endothelial growth factor (VEGF) and may represent a novel repressor of VEGF transcription. In a previous study, our analysis reveals that ZNF24 is a pleiotropic factor that has a role in hematopoiesis, brain development and cancers. Activation of PDGFR-beta is critically involved into various cell functions including recruitment of stromal cells and VEGF induction in tumor and perivascular cells. Here, overexpression of ZNF24 resulted in a significant down-regulation of PDGFR-beta, whereas silencing of ZNF24 with small interfering RNA led to increased PDGFR-beta expression. Overexpression of ZNF24 resulted in a significant decrease in PDGFR-beta promoter activity. These data suggest that ZNF24 is involved in negative regulation of PDGFR-beta and may represent a novel repressor of PDGFR-beta transcription. Crown Copyright (C) 2010 Published by Elsevier Inc. All rights reserved.