Novel T-lymphocyte population in combined immunodeficiency with features of graft-versus-host disease.
Novel T-lymphocyte population in combined immunodeficiency with features of graft-versus-host disease.
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具有移植物抗宿主病特征的联合免疫缺陷中的新型 T 淋巴细胞群。
DOI：
10.1056/nejm198908103210606
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Goldblum,RM
中科院分区：
文献类型：
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作者：
Wirt,DP;Brooks,EG;Vaidya,S;Klimpel,GR;Waldmann,TA;Goldblum,RM
T淋巴细胞在宿主防御中的不同功能是由多个亚群介导的，这些亚群通常根据它们表达表面结构的模式进行分类。大多数成熟的胸腺后T细胞携带T细胞抗原受体(TcRα/β)的α/β形式。这些细胞还分别携带辅助诱导型和抑制型细胞毒亚群特有的CD4或CD8糖蛋白。一小部分循环中的T细胞亚群携带T细胞抗原受体(TcRγ/δ)的另一种伽马/德尔塔形式，但大多数这些细胞既不表达α/β也不表达CD81TcR和TCR.
THE diverse functions of T lymphocytes in the defense of the host are mediated by multiple subpopulations that are often classified by the pattern in which they express surface structures. Most mature, post-thymic T cells bear the alpha/beta form of the T-cell receptor for antigen (TCR α/β). These cells also bear either CD4 or CD8 — glycoproteins characteristic of the helper-inducer and suppressor-cytotoxic subpopulations, respectively. A minor subpopulation of circulating T cells bears an alternative, gamma/delta form of the T-cell receptor for antigen (TCR γ/δ), but most of these cells express neither CD4 nor CD8.1Both TCR α/β and TCR . . .