Anxiety - bridging the heart/mind divide
Anxiety - bridging the heart/mind divide
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DOI：
10.1177/0269881109103800
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发表时间：
2010-05-01
影响因子：
4.1
通讯作者：
Nutt, D. J.
中科院分区：
文献类型：
--
作者：
Davies, S. J. C.;Esler, M.;Nutt, D. J.
尽管几个世纪以来，人们已经认识到心脏和大脑在焦虑中的互补作用，但事实证明，很难描述它们各自的确切贡献，更重要的是，它们之间的相互作用。来自人类大脑成像和心血管生理学研究的最新数据开始描绘一般焦虑症和特别是恐慌的机制途径。大脑γ-氨基丁酸-A和5-羟色胺（5-HT）系统在恐慌和心血管调节功能障碍的证据进行审查沿着新的证据改变交感神经系统的活动在心脏和外周。提出了可检验的假设和研究思路。
Although the complimentary roles of heart and brain in anxiety have been recognised for centuries, the precise contribution of each and more importantly perhaps their interplay has proved difficult to describe. Recent data from human brain imaging and cardiovascular physiology studies are beginning to delineate the mechanistic pathways of anxiety disorders in general and panic in particular. Evidence for a dysfunction of brain gamma-amino butyric acid-A and serotonin (5HT) systems in both panic and cardiovascular regulation is reviewed along with new evidence for altered sympathetic nervous system activity in the heart and periphery. Testable hypotheses and research ideas are suggested.