Structured coalescent processes from a modified Moran model with large offspring numbers
Structured coalescent processes from a modified Moran model with large offspring numbers
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DOI：
10.1016/j.tpb.2009.05.001
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发表时间：
2009-09-01
影响因子：
1.4
通讯作者：
Eldon, Bjarki
中科院分区：
文献类型：
--
作者：
Eldon, Bjarki
在守恒子种群大小的迁移机制下，导出了有限岛模型的结构化合并过程。基本的种群模型是一种改进的Moran模型，在该模型中，繁殖的个体可以以一定的概率产生非常多的后代。当假定迁移遵循的合并时间标度可能比通常的Wright-Fisher时间标度短得多时，收敛到结构化合并过程。根据合并时间刻度的不同，可能有三种不同的限制过程，其中两种允许祖先世系的多次合并。如果合并过程允许多次合并，即使在低迁移时，平衡和不平衡样本到最近共同祖先的预期时间和家谱的预期总大小也可能非常相似。在某些情况下，预期总大小几乎与样本大小呈线性关系。这些结果对遗传群体结构的推断具有重要意义。(C)2009 Elsevier Inc.保留所有权利。
Structured coalescent processes are derived for the finite island model under a migration mechanism that conserves the subpopulation sizes. The underlying population model is a modified Moran model in which the reproducing individual can have very many offspring with some probability. Convergence to a structured coalescent process results when assuming that migration follows a coalescent timescale which can be much shorter than the usual Wright-Fisher timescale. Three different limit processes are possible depending on the coalescent timescale, two of which allow multiple mergers of ancestral lines. The expected time to most recent common ancestor, and the expected total size of the genealogy, of balanced and unbalanced samples can be very similar, even when migration is low, if the coalescent process allows multiple mergers. The expected total size increases almost linearly with sample size in some cases. The results have implications for inference about genetic population structure. (C) 2009 Elsevier Inc. All rights reserved.