Analysis of E6 variants of human papillomavirus type 33, 52 and 58 in Japanese women with cervical intraepithelial neoplasia/cervical cancer in relation to their oncogenic potential
Analysis of E6 variants of human papillomavirus type 33, 52 and 58 in Japanese women with cervical intraepithelial neoplasia/cervical cancer in relation to their oncogenic potential
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DOI：
10.1016/s0304-3835(01)00570-5
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发表时间：
2001-09-10
期刊：
影响因子：
9.7
通讯作者：
Taketani, Y
中科院分区：
文献类型：
--
作者：
Xin, CY;Matsumoto, K;Taketani, Y
人乳头瘤病毒16型(HPV16)E6区变异与宫颈癌发生的高风险有关。为了了解与HPV16高度同源的HPV33、52和58是否也是如此，我们分析了107例日本妇女宫颈上皮内瘤变(CIN)或浸润性宫颈癌(ICC：20例HPV33阳性、46例HPV52阳性和41例HPV58阳性)中这些HPV的E6序列变异。CINS MI组HPV33变异率高于CIN III/ICC组(71%(5/7)和15%(2/13)，P=0.02)。在HPV52阳性的病例中，98%的病例检测到单一的E6变异，而在HPV58阳性的病例中，原型占98%。总之，E6变异体的分布在所测试的HPV类型中是不同的，这表明E6变异体与致癌潜力之间的联系是特定于类型的。(C)2001爱思唯尔爱尔兰科学有限公司。保留所有权利。
The variation of the E6 region of human papillomavirus type 16 (HPV16) is associated with a high risk for cervical carcinogenesis. To see whether the same is the case with HPV33, 52 and 58, known to have high homology with HPV16, we analyzed the E6 sequence variation of these HPVs in 107 Japanese women with cervical intraepithelial neoplasia (CIN) or invasive cervical cancer (ICC: 20 HPV33-positive, 46 HPV52-positive and 41 HPV58-positive cases. HPV33 variants were more frequently observed in CINs MI than in CIN III/ICCs (71% (5/7) versus 15% (2/13), P = 0.02). In HPV52-positive cases, a single E6 variant was detected in 98% of the cases, whereas the prototype accounted for 98% of HPV58-positive cases. In summary, the distribution of E6 variants is different among HPV types tested, suggesting a link between E6 variation and oncogenic potential being type-specific. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.