The intracellular pathogen Orientia tsutsugamushi responsible for scrub typhus induces lipid droplet formation in mouse fibroblasts
The intracellular pathogen Orientia tsutsugamushi responsible for scrub typhus induces lipid droplet formation in mouse fibroblasts
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DOI：
10.1016/j.micinf.2014.09.004
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发表时间：
2014-11-01
影响因子：
5.8
通讯作者：
Ando, Shuji
中科院分区：
文献类型：
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作者：
Ogawa, Motohiko;Fukasawa, Masayoshi;Ando, Shuji
哺乳动物细胞将多余的脂肪酸以甘油三酯的形式储存在脂滴中。胞内恙螨东方体是严重人类立克次体病的病原体。我们发现恙虫病感染诱导小鼠L-929成纤维细胞形成脂滴。在感染细胞中，观察到脂滴和病原体数量的平行增加。有趣的是，即使没有外部脂肪酸供应，病原体感染也会诱导甘油三酯的积累。提示恙虫病虫体通过改变宿主细胞的脂质代谢诱导脂滴形成。(C) 2014巴斯德研究所。Elsevier Masson SAS出版。版权所有。
Mammalian cells store excess fatty acids in the form of triglycerides within lipid droplets. The intracellular bacterium Orientia tsutsugamush is the causative agent of severe human rickettiosis. We found that O. tsutsugamushi infection induces the formation of lipid droplets in mouse L-929 fibroblasts. In infected cells, a parallel increase in the number of lipid droplets and pathogens was observed. Interestingly, the pathogen-infection induced the accumulation of triglycerides even without external supply of fatty acids. These results suggest that O. tsutsugamushi alters lipid metabolism of host cells to induce lipid droplets. (C) 2014 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.