Effects of flecainide on electrophysiological properties of accessory pathways in the Wolff-Parkinson-White syndrome.
Effects of flecainide on electrophysiological properties of accessory pathways in the Wolff-Parkinson-White syndrome.
复制标题
氟卡尼对沃尔夫-帕金森-怀特综合征旁路电生理特性的影响。
作者：
H. Neuss;J. Buss;M. Schlepper;R. Berthold;V. Mitrović;A. Krämer;W. Musiał
本文分析了12例预激综合征（预白色综合征）患者应用氟卡尼后，旁路的顺、逆传导特性，环形运动心动过速的起始和终止方式，以及诱发房颤时的心室反应。这种药物的主要作用是抑制旁路的顺行和逆行传导。8/9例环运动性心动过速通过延长旁道逆行有效不应期而终止。氟卡尼增加了诱发房颤时的最短和平均周期长度。它的结论是，该药物可能是潜在的受益患者阵发性室上性心动过速患者的预激综合征。
The effect of flecainide in 12 patients with the Wolff-Parkinson-White syndrome was analyzed with respect to the anterograde and retrograde conduction properties of the accessory pathway, the modes of initiation and termination of circus movement tachycardias, and the ventricular response during induced atrial fibrillation. The principal effect of this drug was to depress both anterograde and retrograde conduction of the accessory pathway. In 8/9 cases circus movement tachycardia was terminated by prolongation of the retrograde effective refractory period of the accessory pathway. Flecainide increased the shortest and the mean cycle length during induced atrial fibrillation. It is concluded that the drug may be of potential benefit in patients with paroxysmal supraventricular tachycardias in patients with the Wolff-Parkinson-White syndrome.