Characterising eye movement dysfunction in myalgic encephalomyelitis/chronic fatigue syndrome
Characterising eye movement dysfunction in myalgic encephalomyelitis/chronic fatigue syndrome
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DOI：
10.1007/s00417-013-2431-3
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发表时间：
2013-12-01
影响因子：
2.7
通讯作者：
Hutchinson, Claire V.
中科院分区：
文献类型：
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作者：
Badham, Stephen P.;Hutchinson, Claire V.
患有肌痛性脑脊髓炎/慢性疲劳综合征（ME/CFS）的人经常报告说，他们的眼球运动迟缓，难以追踪移动的物体。然而，对这些视觉问题的描述完全基于患者对其主观视觉体验的自我报告，并且明显缺乏经验证据来客观地验证他们的说法。本文首次提出了客观观察ME/CFS患者眼球运动的实验研究。评估患者的ME/CFS症状，并将其与年龄、性别和教育程度相匹配的对照组进行比较，以了解他们产生扫视和平滑眼球运动的能力。患者和对照组在前扫视和反扫视任务上表现出相似的错误率和扫视延迟（反应时间）。患者表现出相对完整的准确固定目标的能力（前眼跳），但当需要准确地聚焦在目标对面的特定位置时（反眼跳）则受损。当要求患者将目光尽可能靠近一个平稳移动的目标（平滑追求）时，患者的视力受损最为明显。据推测，ME/CFS的影响可以短暂地克服，以完成扫视，但持续的追求活动（准确地跟踪移动的物体），即使是很短的时间，也会突出ME/CFS患者的功能失调的眼动行为。今后的顺利开展将有助于进一步阐明和提高ME/CFS的诊断水平。
People who suffer from myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) often report that their eye movements are sluggish and that they have difficulties tracking moving objects. However, descriptions of these visual problems are based solely on patients' self-reports of their subjective visual experiences, and there is a distinct lack of empirical evidence to objectively verify their claims. This paper presents the first experimental research to objectively examine eye movements in those suffering from ME/CFS.Patients were assessed for ME/CFS symptoms and were compared to age, gender, and education matched controls for their ability to generate saccades and smooth pursuit eye movements.Patients and controls exhibited similar error rates and saccade latencies (response times) on prosaccade and antisaccade tasks. Patients showed relatively intact ability to accurately fixate the target (prosaccades), but were impaired when required to focus accurately in a specific position opposite the target (antisaccades). Patients were most markedly impaired when required to direct their gaze as closely as possible to a smoothly moving target (smooth pursuit).It is hypothesised that the effects of ME/CFS can be overcome briefly for completion of saccades, but that continuous pursuit activity (accurately tracking a moving object), even for a short time period, highlights dysfunctional eye movement behaviour in ME/CFS patients. Future smooth pursuit research may elucidate and improve diagnosis of ME/CFS.