Expression of SOX9 in Intraductal Papillary Mucinous Neoplasms of the Pancreas
Expression of SOX9 in Intraductal Papillary Mucinous Neoplasms of the Pancreas
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DOI：
10.1097/mpa.0b013e3182a70b2f
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发表时间：
2014-01
期刊：
影响因子：
2.9
通讯作者：
Fanbin Meng;K. Takaori;Tatsuo Ito;T. Masui;Michiya Kawaguchi;Y. Kawaguchi;S. Uemoto
中科院分区：
文献类型：
--
作者：
Fanbin Meng;K. Takaori;Tatsuo Ito;T. Masui;Michiya Kawaguchi;Y. Kawaguchi;S. Uemoto
目的SRY（sex determining region Y）box 9（SOX 9）基因在胰腺器官的胚胎发育、分化、维持以及多种肿瘤的发生发展中起重要作用。本研究的目的是评估SOX 9在胰腺导管内乳头状粘液性肿瘤（IPMN）中的表达和潜在作用。方法选取19例IPMN患者的27例病理组织，采用免疫组化方法检测SOX 9的表达，并对其中78例进行SOX 9染色，分析SOX 9的表达模式。结果SOX 9在正常胰腺、IPMN和胰腺导管腺癌中均有表达。SOX 9阳性细胞局限于IPMN乳头状结构的下部。然而，一旦肿瘤进展为高度异型增生和浸润性癌，SOX 9在整个上皮中表达。SOX 9在正常胰腺和IPMN中的表达模式与CD 44相似。SOX9和CD44双染色检测到SOX9和CD44在IPMN中共定位。结论SOX 9表达模式的改变可能参与了IPMN的恶性进展。
Objectives SRY (sex determining region Y) box 9 (SOX9) plays a key role in the embryologic development, differentiation, and maintenance of organs in the pancreas as well as progression of several kinds of tumors. The aim of the present study was to evaluate the expression and potential role of SOX9 in intraductal papillary mucinous neoplasms (IPMNs) of the pancreas. Methods The authors selected 27 pathological tissues from 19 IPMN cases to assess the expression of SOX9 by means of immunohistochemistry and analyzed the expression pattern of SOX9 with 78 lesions obtained from these tissues stained by SOX9. Results SOX9 was expressed in the normal pancreas, IPMN, and pancreatic ductal adenocarcinoma. SOX9-positive cells were confined to the lower portions of the papillary structures of IPMN. However, SOX9 was expressed in the entire epithelium once the neoplasms advanced to high-grade dysplasia and invasive carcinoma. The expression pattern of SOX9 was similar to that of CD44 in the normal pancreas and IPMN. Double staining of SOX9 and CD44 detected colocalization of SOX9 and CD44 in IPMN. Conclusions Changes in the SOX9 expression pattern may be involved in the mechanisms of the malignant progression of IPMN.