Radiotherapy and Glioma Stem Cells: Searching for Chinks in Cellular Armor.
Radiotherapy and Glioma Stem Cells: Searching for Chinks in Cellular Armor.
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放射疗法和神经胶质瘤干细胞：在细胞装甲中寻找切换。
DOI：
10.1007/s40778-017-0102-8
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发表时间：
2017-12
影响因子：
1.4
通讯作者：
Ahmed A
中科院分区：
文献类型：
--
作者：
Caragher SP;Sachdev S;Ahmed A
放射治疗在上个世纪成为肿瘤治疗的支柱，并为实体恶性肿瘤提供了强有力和有效的局部治疗。在淋巴瘤和皮肤癌中实现了一些第一次治愈后，它在上皮样恶性肿瘤的治愈性治疗中发挥了关键作用。尽管在各种组织学类型中取得了成功，但胶质母细胞瘤（GBM）是困扰成人的最常见的原发性脑肿瘤，最终仍对当前的放射治疗策略具有抵抗力。虽然GBM表现出初步反应，但复发基本上是普遍和致命的，并且通常在接受最强烈辐射的区域复发。神经胶质瘤干细胞（GSC）是一种具有与神经干细胞相似的表达谱和显著自我更新能力的肿瘤细胞亚群，已被证明可促进肿瘤复发并妨碍治愈性放疗。最近的研究表明，这些细胞具有增强的DNA修复能力，提高了对细胞毒性离子通量的抵抗力，并逃避了多模态治疗。我们将分析目前对GSC和辐射的理解，突出探索其承受放射治疗能力的关键发现。然后，我们推测新的机制，GSC可以敏感或放射治疗的具体目标。
Radiation became a pillar of oncologic treatment in the last century and provided a powerful and effective locoregional treatment of solid malignancies. After achieving some of the first cures in lymphomas and skin cancers, it assumed a key role in curative treatment of epithelioid malignancies. Despite success across a variety of histologic types, glioblastoma (GBM), the most common primary brain tumor afflicting adults, remains ultimately resistant to current radiation strategies. While GBMs demonstrate an initial response, recurrence is essentially universal and fatal, and typically reoccur in the areas that received the most intense radiation. Glioma stem cells (GSCs), a subpopulation of tumor cells with expression profiles similar to neural stem cells and marked self-renewal capacities, have been shown to drive tumor recurrence and preclude curative radiotherapy. Recent research has shown that these cells have enhanced DNA repair capacity, elevated resistance to cytotoxic ion fluxes and escape multi-modality therapies. We will analyze the current understanding of GSCs and radiation by highlighting key discoveries probing their ability to withstand radiotherapy. We then speculate on novel mechanisms by which GSC can be made sensitive to or specifically targeted by radiation therapy.
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影响因子：
11.2
作者：
Hardee ME;Marciscano AE;Medina-Ramirez CM;Zagzag D;Narayana A;Lonning SM;Barcellos-Hoff MH
通讯作者：
Barcellos-Hoff MH
DOI：
10.4161/cc.8.20.9701
发表时间：
2009-10-15
期刊：
Cell cycle (Georgetown, Tex.)
影响因子：
--
作者：
Heddleston JM;Li Z;McLendon RE;Hjelmeland AB;Rich JN
通讯作者：
Rich JN
影响因子：
3.7
作者：
Clarke RH;Moosa S;Anzivino M;Wang Y;Floyd DH;Purow BW;Lee KS
通讯作者：
Lee KS
影响因子：
--
作者：
Brodie S;Lee HK;Jiang W;Cazacu S;Xiang C;Poisson LM;Datta I;Kalkanis S;Ginsberg D;Brodie C
通讯作者：
Brodie C
影响因子：
4.8
作者：
Gabayan, AJ;Green, SB;Stea, B
通讯作者：
Stea, B