Biomechanics of small intestine during distraction enterogenesis with an intraluminal spring
Biomechanics of small intestine during distraction enterogenesis with an intraluminal spring
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DOI：
10.1016/j.jmbbm.2019.103413
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发表时间：
2020-01-01
影响因子：
3.9
通讯作者：
Dunn, James C. Y.
中科院分区：
文献类型：
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作者：
Hosseini, Hadi S.;Taylor, Jordan S.;Dunn, James C. Y.
近年来，牵张肠形成术作为治疗短肠综合征的一种方法得到了广泛的研究，短肠综合征是肠衰竭的最常见原因。虽然不同的策略，如肠外营养和手术延长已被用来管理SBS患者处理的困难，这些治疗与高并发症发生率。牵张肠生成使用机械力来增加小肠的长度并刺激小肠的生长。在这项研究中，我们结合联合收割机在体内实验和计算建模，探讨弹簧依赖性牵张肠形成的生物力学。我们假设自膨胀弹簧为弹性组织延长提供机械力并触发细胞增殖。肠道的额外生长表明机械应力和组织反应之间存在信号传递。我们开发了一个计算建模平台来测试所施加的机械力和组织生长的相关性。我们进一步验证了我们的计算模型与实验测量使用弹簧介导的牵引肠在猪模型。该建模平台可以结合患者生物特征来估计个体对弹簧介导的牵张肠生成的组织响应。
During recent years, distraction enterogenesis has been extensively studied as a treatment for short bowel syndrome, which is the most common cause of intestinal failure. Although different strategies such as parenteral nutrition and surgical lengthening have been used to manage the difficulties that patients with SBS deal with, these treatments are associated with high complication rates. Distraction enterogenesis uses mechanical force to increase the length and stimulate growth of the small intestine. In this study we combine in vivo experiments with computational modeling to explore the biomechanics of spring dependent distraction enterogenesis. We hypothesize that the self-expanding spring provides mechanical force for elastic tissue lengthening and triggers cellular proliferation. The additional growth of the intestine suggests signaling between mechanical stress and tissue response. We developed a computational modeling platform to test the correlation of applied mechanical force and tissue growth. We further validated our computational models with experimental measurements using spring-mediated distraction enterogenesis in a porcine model. This modeling platform can incorporate patient biometrics to estimate an individual's tissue response to spring mediated distraction enterogenesis.