Human leukocyte antigen class-I variation is associated with atopic dermatitis: A case-control study.
Human leukocyte antigen class-I variation is associated with atopic dermatitis: A case-control study.
复制标题
DOI：
10.1016/j.humimm.2021.04.001
复制
发表时间：
2021-08
期刊：
影响因子：
2.7
通讯作者：
Monos DS
中科院分区：
文献类型：
--
作者：
Margolis DJ;Mitra N;Duke JL;Berna R;Margolis JD;Hoffstad O;Kim BS;Yan AC;Zaenglein AL;Chiesa Fuxench Z;Dinou A;Wasserman J;Tairis N;Mosbruger TL;Ferriola D;Damianos G;Kotsopoulou I;Monos DS
Atopic dermatitis (AD) is a common immune-medicated skin disease. Previous studies have explored the relationship between Human Leukocyte Antigen (HLA) allelic variation and AD with conflicting results. The aim was to examine HLA Class I genetic variation, specifically peptide binding groove variation, and associations with AD. A case-control study was designed to evaluate HLA class I allelic variation and binding pocket polymorphisms, using next generation sequencing on 464 subjects with AD and 388 without AD. Logistic regression was used to evaluate associations with AD by estimating odds ratios (95% confidence intervals). Significant associations were noted with susceptibility to AD (B*53:01) and protection from AD (A*01:01, A*02:01, B*07:02 and C*07:02). Evaluation of polymorphic residues in Class I binding pockets revealed six amino acid residues conferring protection against AD: A9F (HLA-A, position 9, phenylalanine) [pocket B/C], A97I [pocket C/E], A152V [pocket E], A156R [pocket D/E], B163E [pocket A] and C116S [pocket F]. These findings demonstrate that specific HLA class I components are associated with susceptibility or protection from AD. Individual amino acid residues are relevant to protection from AD and set the foundation for evaluating potential HLA Class I molecules in complex with peptides/antigens that may initiate or interfere with T-cell responses.
登录
查看更多内容
影响因子：
2.6
作者：
Gough SC;Simmonds MJ
通讯作者：
Simmonds MJ
影响因子：
3.5
作者：
Niepieklo-Miniewska, Wanda;Majorczyk, Edyta;Kusnierczyk, Piotr
通讯作者：
Kusnierczyk, Piotr
影响因子：
2.7
作者：
Margolis DJ;Mitra N;Kim B;Gupta J;Hoffstad OJ;Papadopoulos M;Wubbenhorst B;Nathanson KL;Duke JL;Monos DS;Kamoun M
通讯作者：
Kamoun M
影响因子：
17.1
作者：
Mack, Madison R.;Brestoff, Jonathan R.;Kim, Brian S.
通讯作者：
Kim, Brian S.
影响因子：
1.5
作者：
Martinez-Camblor, P.;Perez-Fernandez, S.;Diaz-Coto, S.
通讯作者：
Diaz-Coto, S.