Cardiovascular actions of microinjections of angiotensin II in the brain stem of rats.
Cardiovascular actions of microinjections of angiotensin II in the brain stem of rats.
复制标题
大鼠脑干显微注射血管紧张素 II 的心血管作用。
DOI：
10.1152/ajpregu.1984.246.5.r811
复制
发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Phillips,MI
中科院分区：
文献类型：
--
作者：
Casto,R;Phillips,MI
本文观察了脑干内微量注射血管紧张素Ⅱ（ANG Ⅱ）对麻醉大鼠血压和心率的影响。最后区（AP）微量注射ANG Ⅱ可使血压显著升高，心率显著减慢。微量注射到孤束核（NTS）的区域产生了显着的剂量依赖性升高血压和一致的心率增加。ANG II微量注射到NTS区域的反应不是由于泄漏到外周循环，因为静脉注射ANG II拮抗剂saralasin，没有减弱反应。事实上，外周血管紧张素II阻滞后心血管反应增加，心率在saralasin预处理后显著升高，而单独注射NTS后心率一直但不显著升高。AP的热消融没有改变心率或对NTS区域微量注射ANG II的升压反应，表明该反应不是通过AP介导的。
The blood pressure and heart rate responses to microinjection of angiotensin II (ANG II) into the brain stem of urethan-anesthetized rats were studied. Microinjection of ANG II into the area postrema (AP) resulted in significant elevation of blood pressure and significant reduction of heart rate. Microinjection into the region of the nucleus tractus solitarius (NTS) yielded a significant dose-dependent elevation in blood pressure and consistent increases in heart rate. The response to microinjection of ANG II into the region of the NTS was not due to leakage into the peripheral circulation, since intravenous administration of the ANG II antagonist, saralasin, did not attenuate the response. In fact, the cardiovascular response was increased after peripheral ANG II blockade, and the heart rate, which was consistently but not significantly elevated by NTS injection alone, was significantly elevated after saralasin pretreatment. Thermal ablation of the AP did not change the heart rate or the pressor response to microinjection of ANG II into the region of the NTS, indicating that the response was not mediated through the AP.