PCB exposure in utero and via breast milk.: A review
PCB exposure in utero and via breast milk.: A review
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DOI：
10.1038/sj.jea.7500090
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发表时间：
2000-05-01
期刊：
影响因子：
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通讯作者：
Karmaus, W
中科院分区：
文献类型：
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作者：
Dekoning, EP;Karmaus, W
对文献进行了回顾，以调查子宫内和母乳中多氯联苯（PCB）暴露对后代的重要性。纳入了我们能够识别的所有报告（n=25），代表16个研究人群。比较了人体胎盘、母乳、母体血液和脐带血中特定组织的多氯联苯浓度，以确定各组织间的蓄积率。以脂质为基础，胎盘中多氯联苯的最高浓度（5027纳克/克脂肪）比母乳中多氯联苯的最高浓度（1770纳克/克脂肪）高2.8倍。虽然有关于定量方法和统计方法所使用的审查研究的局限性，我们的研究结果表明，多氯联苯可能能够通过胎盘在更大程度上比以前认为的。未来围产期多氯联苯体内负荷的研究应包括胎盘、母乳、母体和脐带血标本。为了比较多氯联苯在各种组织中的浓度，并与其他研究，浓度应确定在脂质的基础上。
A review of the literature was conducted to investigate the importance to offspring of in utero and breast milk polychlorinated biphenyl (PCB) exposure. All reports that we could identify (n=25) were included, representing 16 study populations. Tissue-specific PCB concentrations in human placenta, breast milk, maternal blood and cord blood were compared to determine accumulation ratios between tissue compartments. On a lipid basis, the highest concentration of PCB in placenta (5027 ng/g fat) was 2.8 times higher than the highest concentration of PCB in breast milk (1770 ng/g fat). While there are limitations with regard to quantitation methods and statistical methods utilized by the reviewed studies, our results suggest that PCBs may be capable of crossing the placenta to a greater extent than previously believed. Future studies of PCB body burden in the perinatal period should include placenta, breast milk, maternal and cord blood specimens. In order to compare PCB concentrations in various tissues and with other studies, concentrations should be determined on a lipid basis.