Evaluation of the interaction of surfactants with stratum corneum model membrane from Bothrops jararaca by DSC
Evaluation of the interaction of surfactants with stratum corneum model membrane from Bothrops jararaca by DSC
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DOI：
10.1016/j.ijpharm.2006.04.006
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发表时间：
2006-07-06
影响因子：
5.8
通讯作者：
Kaneko, Telma Mary
中科院分区：
文献类型：
--
作者：
Baby, Andre Rolim;Lemos Lacerda, Aurea Cristina;Kaneko, Telma Mary
The interaction of surfactants sodium dodecyl sulfate (SDS), cetyl trimethyl ammonium chloride (CTAC) and lauryl alcohol ethoxylated (12 molethylene oxide) (LAE-120E) was evaluated on the stratum corneum (SC) of shed snake skins from Bothrops jararaca, used as model membrane, and thermal characterized by differential scanning calorimetry (DSC). Surfactant solutions were employed above of the critical micellar concentration (CMC) with treatment time of 8 h. The SDS interaction with the SC model membrane has increased the characteristic transition temperature of 130 degrees C in approximate to 10 degrees C for the water loss and keratin denaturation, indicating an augmentation of the water content. Samples treated with CTAC have a decrease of the water loss temperature, while, for the LAE-120E treated samples, changes on the transition temperature have not been observed. (c) 2006 Elsevier B.V. All rights reserved.
