Expression patterns of mouse and human CYP orthologs (families 1-4) during development and in different adult tissues
Expression patterns of mouse and human CYP orthologs (families 1-4) during development and in different adult tissues
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DOI：
10.1016/j.abb.2005.02.001
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发表时间：
2005-04-01
影响因子：
3.9
通讯作者：
Schenkman, JB
中科院分区：
文献类型：
--
作者：
Choudhary, D;Jansson, I;Schenkman, JB
本研究比较了来自家族1-4的10种同源CYP形式在人和小鼠胎儿和成人组织cDNA面板中的相对表达模式。除CYP1A2外，所有这些CYPs在小鼠个体发育过程中都表现出特定的表达模式，表明可能参与发育。Cyp1a1和Cyp2r1是仅有的两个仅在E7小鼠中表达的同源物；Cyp2s1在包括E7在内的所有阶段均有表达，而Cyp2e1仅在E17出现。个体CYPs在不同晚期人胎组织中表达量最高的是：胸腺、CYP1B1和CYP2U1；肝CYP2E1;大脑，CYP2R1， CYP1A1和CYP4X1；CYP4B1和CYP2W1。一般来说，胎儿个体CYP转录本的水平低于相应的成人组织。CYP1A1、CYP1A2在成年小鼠和人组织中的表达模式相当相似。CYP1B1， CYP2S1和CYP2U1同源物。(c) 2005爱思唯尔公司版权所有。
The present study compared the relative expression pattern of 10 orthologous CYP forms from families 1-4 in cDNA panels of human and mouse fetal and adult tissues. Except for CYP1A2, all of these CYPs exhibited specific patterns of expression during Mouse ontogeny, suggesting possible involvement in development. Cyp1a1 and Cyp2r1 were the only two of the orthologs to be expressed only in the E7 mouse; Cyp2s1 was expressed in all stages, including E7, while Cyp2e1 appeared only at E17. Highest expression of the individual CYPs in the different late term human fetal tissues was: thymus, CYP1B1 and CYP2U1; liver, CYP2E1; brain, CYP2R1, CYP1A1 and CYP4X1; and lung, CYP4B1 and CYP2W1. In general, the level of individual human CYP transcripts was lower in the fetal than the corresponding adult tissues. The pattern of expression in adult mouse and human tissues was fairly similar for CYP1A1, CYP1A2. CYP1B1, CYP2S1, and CYP2U1 orthologs. (c) 2005 Elsevier Inc. All rights reserved.