Causal Association Between Alcohol Consumption and Atrial Fibrillation: A Mendelian Randomization Study.
Causal Association Between Alcohol Consumption and Atrial Fibrillation: A Mendelian Randomization Study.
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DOI：
10.4070/kcj.2021.0269
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发表时间：
2022-03
影响因子：
2.9
通讯作者：
Shin MH
中科院分区：
文献类型：
--
作者：
Yang JH;Jeong JA;Kweon SS;Lee YH;Choi SW;Ryu SY;Nam HS;Park KS;Kim HY;Shin MH
先前的观察性研究表明酒精与房颤（AF）之间存在正相关。然而，以前的研究使用遗传多态性对酒精消费和AF之间的因果关系报告了相互矛盾的结果。本研究使用乙醛脱氢酶2（ALDH2）rs671多态性评价了饮酒与AF之间的因果关系。在8，964名队列参与者中，使用ALDH2基因型进行的遗传分析和孟德尔随机化分析显示，男性饮酒与AF之间存在显著的因果关系。先前的观察性研究表明酒精与房颤（AF）之间存在正相关。然而，以前的研究使用遗传多态性对酒精消费和AF之间的因果关系报告了相互矛盾的结果。本研究旨在使用乙醛脱氢酶2（ALDH2）rs671多态性评估饮酒与AF之间的因果关系，这是对饮酒行为影响最大的遗传变异。本研究共纳入了来自东谷研究的8，964名参与者。通过使用ALDH2 rs671多态性作为工具变量的孟德尔随机化（MR）分析，评估饮酒与AF之间的因果关系。在观察性分析中未发现饮酒与AF之间存在显著相关性。然而，使用ALDH2多态性的遗传分析显示，在男性中存在显著关联。在MR分析中，遗传预测的每日饮酒量与AF呈正相关。MR分析显示饮酒量与AF之间存在显著相关性，这表明该相关性可能是因果关系。
Previous observational studies presented a positive association between alcohol and atrial fibrillation (AF). However, previous studies using genetic polymorphisms on the causal relationship between alcohol consumption and AF have reported conflicting results. This study evaluated the causality between alcohol consumption and AF using the aldehyde dehydrogenase 2 (ALDH2) rs671 polymorphism. In 8,964 cohort participants, genetic analysis and Mendelian randomization analysis using the ALDH2 genotypes showed a significant causal association between alcohol consumption and AF in men. Previous observational studies presented a positive association between alcohol and atrial fibrillation (AF). However, previous studies using genetic polymorphisms on the causal relationship between alcohol consumption and AF have reported conflicting results. This study aimed to evaluate the causality between alcohol consumption and AF using the aldehyde dehydrogenase 2 (ALDH2) rs671 polymorphism, which is the genetic variant with the most potent effect on drinking behavior. A total of 8,964 participants from the Dong-gu Study were included in the present study. The causal association between alcohol consumption and AF was evaluated through a Mendelian randomization (MR) analysis using the ALDH2 rs671 polymorphism as an instrumental variable. No significant relationship between alcohol consumption and AF was found in the observational analysis. However, the genetic analysis using the ALDH2 polymorphism showed a significant association in men. In the MR analysis, genetically predicted daily alcohol consumption was positively related to AF. MR analysis revealed a significant association between the amount of alcohol consumption and AF, which suggests that the association may be causal.