Long-term follow-up of visual functions in prematurely born children -: a prospective population-based study up to 10 years of age
Long-term follow-up of visual functions in prematurely born children -: a prospective population-based study up to 10 years of age
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DOI：
10.1016/j.jaapos.2007.08.012
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发表时间：
2008-04-01
期刊：
影响因子：
1.6
通讯作者：
Larsson, Eva
中科院分区：
文献类型：
--
作者：
Holmstrom, Gerd;Larsson, Eva
前言早产儿有增加的风险眼科问题。对于如何遵循这些原则，仍然没有达成共识。本研究的目的是评估预测因素的问题，早产儿在10岁，并讨论后续recommendations.MATERIALS和METHODS一百九十九名儿童与出生体重为1500克或更少筛选视网膜病变的早产儿（ROP）在新生儿期，此后眼科检查在6个月，1.5，2.5，3.5，和10岁之间。10岁时的“视觉功能障碍”定义为视敏度>= 0.1 logMAR和/或斜视和/或对比敏感度低于正常。多元回归分析被用来评估风险因素在早期的年龄，可以预测在10岁的问题。结果25%的队列有视觉功能障碍在10岁。神经系统并发症、冷冻治疗ROP、屈光参差和散光是危险因素。当所有儿童在2.5岁时有神经系统并发症、冷冻治疗的ROP、斜视、屈光参差>= 1屈光度（D），2.5年的散光2 D纳入进一步随访。早产儿应在治疗ROP和/或神经系统疾病的患者中进行。对于没有此类问题的第三组，建议至少进行一次随访。这样的检查也提供了一个很好的机会，以确定神经系统的问题，保证进一步眼科随访。
INTRODUCTION Prematurely born children have an increased risk of ophthalmologic problems. There is still no consensus on how they should be followed. The purpose of this study was to evaluate predictive factors for problems in premature children at ten years of age and to discuss follow-up recommendations.MATERIALS AND METHODS One hundred ninety-nine children with a birth weight of 1500 g or less were screened for retinopathy of prematurity (ROP) in the neonatal period and thereafter ophthalmologically examined at 6 months, 1.5, 2.5, 3.5, and 10 years of age. "Visual dysfunction" at ten years of age was defined as visual acuity >= 0.1 logMAR and/or strabismus and/or subnormal contrast sensitivity. Multiple regression analyses were used to evaluate risk factors at an early age, which could predict problems at ten years of age.RESULTS Twenty-five percent of the cohort had visual dysfunction at ten years of age. Neurological complications, cryotreated ROP, anisometropia, and astigmatism were risk factors. The sensitivity was 75.5%, and the specificity 80.7% for the detection of visual dysfunction at ten years of age when all children with neurological complications, cryotreated ROP, strabismus, anisometropia >= 1 diopters (D) at 2.5 years, and astigmatism 2 D at 2.5 years were included in further follow-up.CONCLUSIONS Repeated ophthalmologic follow-up of prematurely born children should be performed in those with treated ROP and/or neurological conditions. For a third group without such problems, at least one follow-up is recommended. Such an examination also provides a good opportunity to identify neurological problems that warrant further ophthalmologic follow-up.