REVERSAL OF STRESS-INDUCED ANHEDONIA BY THE ATYPICAL ANTIDEPRESSANTS, FLUOXETINE AND MAPROTILINE
REVERSAL OF STRESS-INDUCED ANHEDONIA BY THE ATYPICAL ANTIDEPRESSANTS, FLUOXETINE AND MAPROTILINE
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DOI：
10.1007/bf02247719
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发表时间：
1992-12-01
影响因子：
3.4
通讯作者：
WILLNER, P
中科院分区：
文献类型：
--
作者：
MUSCAT, R;PAPP, M;WILLNER, P
长期暴露于温和的不可预测的压力之前已被发现抑制可口的甜溶液的消费。在本研究中，这种作用被非典型抗抑郁药氟西汀和马普替林（5 mg/kg/天）长期（9周）治疗逆转，非抗抑郁药利血平无效。应激动物在位置条件反射程序中对食物奖励也不敏感：然而，氟西汀和马普替林处理的动物显示出正常的位置偏好条件反射。急性预处理雷氯必利（100微克/公斤）选择性逆转恢复蔗糖饮用抗抑郁药治疗的压力动物。这些结果扩展了以前的三环类抗抑郁药在这种模式下的疗效报告，并支持多巴胺能抗抑郁作用机制的假设。
Chronic exposure to mild unpredictable stress has previously been found to depress the consumption of palatable sweet solutions. In the present study this effect was reversed by chronic (9 weeks) treatment with the atypical antidepressants, fluoxetine and maprotiline (5 mg/kg/day), the non-antidepressant chlordiazepoxide was ineffective. Stressed animals were also subsensitive to food reward in the place conditioning procedure: however, fluoxetine and maprotiline treated animals showed normal place preference conditioning. Acute pretreatment with raclopride (100 mug/kg) selectively reversed the recovery of sucrose drinking in antidepressant-treated stressed animals. These results extend previous reports of the efficacy of tricyclic antidepressants in this paradigm, and support the hypothesis of a dopaminergic mechanism of antidepressant action.