In vitro evaluation of prestorage pooled leukoreduced whole blood-derived platelets stored for up to 7 days
In vitro evaluation of prestorage pooled leukoreduced whole blood-derived platelets stored for up to 7 days
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DOI：
10.1111/j.1537-2995.2005.04234.x
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发表时间：
2005-06-01
期刊：
影响因子：
2.9
通讯作者：
Kelton, JG
中科院分区：
文献类型：
--
作者：
Heddle, NM;Barty, RL;Kelton, JG
背景资料：将全血衍生的血小板（PLT）作为池储存7天的优点将包括操作效率和促进细菌测试和病原体灭活。研究设计和方法：Leukoreduced PLT在储存前合并（5个单位/池），储存5或7天。在合并时和第5天（n=16-29）或第7天（n=4-30）采集样品，并检测生化和活化标志物以及形态和/或形状变化。结果：平均血小板计数（x10（9）/L）相似：对照组血小板，1344（464 SD）;储存前合并的血小板，1327（220 SD; p=0.93）。第5天，pH值显著降低（p
Background: Advantages to storing whole blood-derived platelets (PLTs) as a pool for 7 days would include operational efficiencies and facilitation of bacterial testing and pathogen inactivation. The in vitro quality of pre-storage pooled PLTs stored for up to 7 days was assessed.Study Design and Methods: Leukoreduced PLTs were pooled before storage (5 units/pool) and stored for either 5 or 7 days. Samples were collected at the time of pooling and either on Day 5 (n=16-29) or on Day 7 (n=4-30) and tested for biochemical and activation markers and morphology and/or shape change. Control PLTs were stored individually for 5 or 7 days and then tested as indicated above.Results: The mean PLT counts (x10(9)/L) were similar: control PLTs, 1344 (464 SD); and prestorage pooled PLTs, 1327 (220 SD; p=0.93). On Day 5, the pH value was significantly lower (p