DSigDB: drug signatures database for gene set analysis

DSigDB: drug signatures database for gene set analysis
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DOI:
10.1093/bioinformatics/btv313
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发表时间:
2015-09-15
期刊:
影响因子:
5.8
通讯作者:
Tan, Aik Choon
Tan, Aik Choon
中科院分区:
生物学3区
文献类型:
--
作者:
Yoo, Minjae;Shin, Jimin;Tan, Aik Choon

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我们报告了药物特征数据库(DSigDB)的创建,这是一种新的基因集资源,涉及药物/化合物及其靶基因,用于基因集富集分析(GSEA)。DSigDB目前拥有22 527个基因集,由17 389个独特的化合物组成,覆盖19 531个基因。我们还开发了一个在线DSigDB资源,允许用户搜索,查看和下载药物/化合物和基因集。DSigDB基因集提供与GSEA软件的无缝集成,用于将基因表达与药物/化合物联系起来,以进行药物再利用和转化研究。
We report the creation of Drug Signatures Database (DSigDB), a new gene set resource that relates drugs/compounds and their target genes, for gene set enrichment analysis (GSEA). DSigDB currently holds 22 527 gene sets, consists of 17 389 unique compounds covering 19 531 genes. We also developed an online DSigDB resource that allows users to search, view and download drugs/compounds and gene sets. DSigDB gene sets provide seamless integration to GSEA software for linking gene expressions with drugs/compounds for drug repurposing and translational research.