Genetic Overlap Between Measures of Hyperactivity/Inattention and Mood in Children and Adolescents
Genetic Overlap Between Measures of Hyperactivity/Inattention and Mood in Children and Adolescents
复制标题
DOI：
10.1097/chi.0b013e3181b7666e
复制
发表时间：
2009-11-01
影响因子：
13.3
通讯作者：
McGuffin, Peter
中科院分区：
文献类型：
--
作者：
Cole, James;Ball, Harriet A.;McGuffin, Peter
目的：有证据表明，注意缺陷多动障碍(ADHD)和重度抑郁障碍在儿童期和青春期有很大的共病。这项研究的目的是调查这些显着可遗传疾病的症状之间的病因共享程度。方法：采用双生子研究设计，根据父母的报告，确定ADHD和抑郁症之间的共同变异在多大程度上是由遗传或环境调节的。来自加的夫全威尔士和英格兰北部双胞胎研究项目的645对年龄在5到17岁之间的双胞胎一般社区样本参与了这项研究。父母评定的多动/注意力不集中(简写为Conners多动子量表)和抑郁(简短的情绪和感觉问卷)。结果：从量表得出的表型在男孩和女孩中都有显著的相关性。双变量结构方程模型显示潜在遗传因素有很大的重叠(男孩，r(A)=0.77；女孩，r(A)=0.67)，而非共享环境的影响较小。结论：这些发现表明，在儿童和青少年中，有共同的基因与多动/注意力不集中和抑郁特征有关。这对未来ADHD和严重抑郁障碍的分子遗传学研究具有重要意义。此外，它还表明，这些疾病的共病临床表现可能反映了一种共同的遗传途径。上午1：00阿卡德。青春期儿童。精神病学，2009；48(11)：1094-1101。
Objective: Evidence suggests that there is substantial comorbidity between attention-deficit/hyperactivity disorder (ADHD) and major depressive disorder in childhood and adolescence. This study aims to investigate the degree to which etiological factors are shared between the symptoms of these significantly heritable disorders. Method: A twin study design was used to determine to what extent the covariation between the traits of ADHD and depression is genetically or environmentally mediated, based on parental reports. A general community sample of 645 twin pairs aged 5 to 17 years from the Cardiff Study of All Wales and North England Twins project took part in the study. Parent-rated measures of hyperactivity/inattention (Abbreviated Conners Hyperactivity subscale) and depression (Short Mood and Feelings Questionnaire). Results: Phenotypes derived from the scales were significantly correlated in both boys and girls. Bivariate structural equation modeling revealed a large overlap in underlying genetic factors (boys, r(A) = 0.77; girls, r(A) = 0.67) along with a smaller influence of nonshared environment. Conclusions: These findings suggest that there are common genes conferring liability to both hyperactive/inattentive and depressive traits in children and adolescents. This has implications for future molecular genetic research into ADHD and major depressive disorder. Additionally, it indicates that the comorbid clinical presentation of these disorders may reflect a common genetic pathway. J Am. Acad. Child Adolesc. Psychiatry, 2009;48(11):1094-1101.