Animal models for human group 1 CD1 protein function
Animal models for human group 1 CD1 protein function
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DOI：
10.1016/j.molimm.2020.12.018
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发表时间：
2021-01-13
影响因子：
3.6
通讯作者：
Bastian，Max
中科院分区：
文献类型：
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作者：
Eckhardt，Emmelie;Bastian，Max
CD 1抗原呈递系统在进化上是保守的，并且在哺乳动物、鸟类和爬行动物中发现。人类表达五种亚型，其中CD 1a、CD 1b和CD 1c代表第1组CD 1分子。它们被表达不同αβ-T细胞受体的T细胞识别。由于小鼠不表达CD 1a、CD 1b和CD 1c，因此对第1组CD 1功能作用的研究受到阻碍。然而，其他动物，如豚鼠或牛，可作为替代模型，并已建立了CD 1依赖性抗菌免疫功能的基本方面。第1组CD 1转基因小鼠模型在大约10年前出现。在一系列开创性的研究中，这些小鼠模型创造了对相应的CD 1限制性T细胞应答的作用的机械理解。这篇综述简要概述了现有的动物研究和已经和仍然可以吸取的教训。
The CD1 antigen presenting system is evolutionary conserved and found in mammals, birds and reptiles. Humans express five isoforms, of which CD1a, CD1b and CD1c represent the group 1 CD1-molecules. They are recognized by T cells that express diverse αβ-T cell receptors. Investigation of the role of group 1 CD1 function has been hampered by the fact that CD1a, CD1b and CD1c are not expressed by mice. However, other animals, such as guinea pigs or cattle, serve as alternative models and have established basic aspects of CD1-dependent, antimicrobial immune functions. Group 1 CD1 transgenic mouse models became available about ten years ago. In a series of seminal studies these mouse models coined the mechanistical understanding of the role of the corresponding CD1 restricted T cell responses. This review gives a short overview of available animal studies and the lessons that have been and still can be learned.