Food transport in the C-elegans pharynx
Food transport in the C-elegans pharynx
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DOI：
10.1242/jeb.00433
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发表时间：
2003-07-01
影响因子：
2.8
通讯作者：
Shtonda, BB
中科院分区：
文献类型：
--
作者：
Avery, L;Shtonda, BB
线虫咽部的泵送将食物颗粒（细菌）向后输送。我们检查了肌肉运动以确定这种后部运输是如何实现的。我们发现咽中部（前峡部）的运动相对于前部（语体）延迟。假设颗粒在未被咽腔壁捕获时以平均流体速度移动的模拟表明，延迟的峡部运动确实会导致净颗粒传输；然而，其量比真正咽中的量要少得多。我们提出咽腔的几何形状迫使颗粒向中心移动，在那里它们的移动速度比平均流体速度更快。当这种加速度被纳入模拟时，粒子就会被有效地传输。我们提出的转运机制解释了过去的观察结果，即肌肉放松的时间对于有效转运很重要。我们的模型还做出了预测，我们证实了较小的细菌比大的细菌是线虫更好的食物来源。
Pumping of the C elegans pharynx transports food particles (bacteria) posteriorly. We examined muscle motions to determine how this posterior transport is effected. We find that the motions of the middle section of the pharynx, the anterior isthmus, are delayed relative to the anterior section, the corpus. Simulations in which particles are assumed to move at mean fluid velocity when not captured by the walls of the pharyngeal lumen show that delayed isthmus motions do indeed cause net particle transport; however, the amount is much less than in the real pharynx. We propose that the geometry of the pharyngeal lumen forces particles to the center, where they move faster than mean fluid velocity. When this acceleration is incorporated into the simulation, particles are transported efficiently. The transport mechanism we propose explains past observations that the timing of muscle relaxation is important for effective transport. Our model also makes A prediction, which we confirm, that smaller bacteria are better food sources for C elegans than large ones.