Effects of morphine, ethylketocyclazocine, and N-allylnormetazocine on classical conditioning of the rabbit nictitating membrane response.
Effects of morphine, ethylketocyclazocine, and N-allylnormetazocine on classical conditioning of the rabbit nictitating membrane response.
复制标题
吗啡、乙基酮环佐辛和 N-烯丙去甲佐辛对兔瞬膜反应经典调节的影响。
DOI：
10.1037//0735-7044.100.5.647
复制
发表时间：
1986
影响因子：
1.9
通讯作者：
Harvey,JA
中科院分区：
文献类型：
--
作者：
Schindler,CW;Lamb,MR;Gormezano,I;Harvey,JA
The nictitating membrane response of 120 New Zealand albino rabbits was classically conditioned to tone and light conditioned stimuli (CSs) presented for 800 msec before delivery of a 100-msec unconditioned shock stimulus. Both the mu receptor agonist morphine (5 mg/kg) and the kappa receptor agonist ethylketocyclazocine (1 mg/kg) significantly retarded the acquisition of conditioned responses (CRs). The retardant effects of both morphine and ethylketocyclazocine on CR acquisition could still be detected when the Ss were tested 5 days after cessation of drug injections. The sigma receptor agonist N-allylnormetazocine (5 mg/kg) had no effect on acquisition. The retardant effects of morphine and ethylketocyclazocine on acquisition were significantly antagonized by both naloxone (1 mg/kg) and N-allylnormetazocine. It is suggested that mu and possibly kappa receptors are involved in the retardant effects of opiates on CR acquisition.(14 ref)(PsycINFO Database Record (c) 2016 APA, all rights reserved)
