Pulmonary Thermal Ablation: Comparison of Radiofrequency and Microwave Devices by Using Gross Pathologic and CT Findings in a Swine Model
Pulmonary Thermal Ablation: Comparison of Radiofrequency and Microwave Devices by Using Gross Pathologic and CT Findings in a Swine Model
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DOI：
10.1148/radiol.2513081564
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发表时间：
2009-06-01
期刊：
影响因子：
19.7
通讯作者：
Lee, Fred T., Jr.
中科院分区：
文献类型：
--
作者：
Brace, Christopher L.;Hinshaw, J. Louis;Lee, Fred T., Jr.
目的：为了比较在正常的猪肺model.Materials和方法：所有实验的机构的动物护理和使用委员会批准的同等大小的射频和微波消融applicators的性能。在正常猪肺中共进行了18次体内消融。通过使用计算机断层扫描（CT）透视引导，经皮放置17 G冷却三轴微波天线（n = 9）和17 G冷却射频（RF）电极（n = 9）。使用125 W微波功率或200 W射频功率（采用基于阻抗的脉冲算法）进行消融10分钟。在消融期间每分钟采集一次CT图像以监测生长。手术后处死动物。然后切除消融区，并以5 mm的增量横切施用器。根据大体标本和CT图像测量最小和最大直径、横截面积、长度和圆形度。通过使用混合效应模型进行每个测量的比较; P <0.05被认为指示显著差异。平均直径（3.32 cm +/- 0.19 [标准差] vs 2.70 cm +/- 0.23，P < .001），微波消融和平均横截面积增加25与射频消融术相比，微波消融术（8.25 cm（2）+/- 0.92 vs 5.45 cm（2）+/- 1.14，P <0.001）大50%。在微波消融中，消融区域的横截面也明显更圆（平均圆度，0.90 +/- 0.06 vs 0.82 +/- 0.09; P <0.05）。一个小气胸，在射频消融过程中，但没有intervention.Conclusion稳定：微波消融与17号高功率三轴天线创建更大，更圆的消融区比一个类似大小的射频施加器在临床前动物模型。微波消融可能是肺肿瘤的一种更有效的治疗方法。(C)RSNA，2009年
Purpose: To compare the performance of equivalently sized radio-frequency and microwave ablation applicators in a normal porcine lung model.Materials and Methods: All experiments were approved by an institutional animal care and use committee. A total of 18 ablations were performed in vivo in normal porcine lungs. By using computed tomographic (CT) fluoroscopic guidance, a 17-gauge cooled triaxial microwave antenna (n = 9) and a 17-gauge cooled radiofrequency (RF) electrode (n = 9) were placed percutaneously. Ablations were performed for 10 minutes by using either 125 W of microwave power or 200Wof RF power delivered with an impedance-based pulsing algorithm. CT images were acquired every minute during ablation to monitor growth. Animals were sacrificed after the procedure. Ablation zones were then excised and sectioned transverse to the applicator in 5-mm increments. Minimum and maximum diameter, cross-sectional area, length, and circularity were measured from gross specimens and CT images. Comparisons of each measurement were performed by using a mixed-effects model; P < .05 was considered to indicate a significant difference.Results: Mean diameter (3.32 cm +/- 0.19 [standard deviation] vs 2.70 cm +/- 0.23, P < .001) was 25% larger with microwave ablation and mean cross-sectional area (8.25 cm(2) +/- 0.92 vs 5.45 cm(2) +/- 1.14, P < .001) was 50% larger with microwave ablation, compared with RF ablation. With microwave ablation, the zones of ablation were also significantly more circular in cross section (mean circularity, 0.90 +/- 0.06 vs 0.82 +/- 0.09; P < .05). One small pneumothorax was noted during RF ablation but stabilized without intervention.Conclusion: Microwave ablation with a 17-gauge high-power triaxial antenna creates larger and more circular zones of ablation than does a similarly sized RF applicator in a preclinical animal model. Microwave ablation may be a more effective treatment of lung tumors. (C) RSNA, 2009