Macrophage-adipocyte communication and cardiac remodeling.

Macrophage-adipocyte communication and cardiac remodeling.
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DOI:
10.1084/jem.20211098
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发表时间:
2021-09-06
期刊:
The Journal of experimental medicine
影响因子:
--
通讯作者:
Ramasamy R
Ramasamy R
中科院分区:
其他
文献类型:
--
作者:
Yepuri G;Hasan SN;Schmidt AM;Ramasamy R

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JEM 最近发表的一项研究描述了脂肪细胞与巨噬细胞的合作,通过血管紧张素 II 在肥胖症中的作用促进心脏纤维化。在肥胖并发高血压的情况下,多细胞过程整合以协调心脏纤维化;然而,其根本机制仍然难以捉摸。在本期《JEM》中,Cheng 等人。 (2021. J. Exp. Med. https://doi.org/10.1084/jem.20210252) 描述了脂肪细胞-巨噬细胞协作通过血管紧张素 II 在肥胖症中的作用促进心脏纤维化。
A recent study published in JEM describes the adipocyte–macrophage collaboration to foster cardiac fibrosis through the actions of angiotensin II in obesity. In obesity complicated by hypertension, multicellular processes integrate to orchestrate cardiac fibrosis; the underlying mechanisms, however, remain elusive. In this issue of JEM, Cheng et al. (2021. J. Exp. Med. https://doi.org/10.1084/jem.20210252) describe adipocyte–macrophage collaboration to foster cardiac fibrosis through the actions of angiotensin II in obesity.
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