The role of leukemia inhibitory factor in skeletal muscle regeneration
The role of leukemia inhibitory factor in skeletal muscle regeneration
复制标题
白血病抑制因子在骨骼肌再生中的作用
作者：
J. Kurek;J. Bower;M. Romanella;Frank Koentgen;M. Murphy;L. Austin
虽然许多细胞因子与组织再生有关，但尚不清楚哪些细胞因子在体内实际起作用。在这里，我们使用白血病抑制因子（LIF）基因发生靶向突变的小鼠来研究LIF在肌肉再生中的作用。使用肌肉挤压模型，我们表明，在LIF基因敲除小鼠的肌肉再生显着减少相比，控制同窝出生。此外，在正常和LIF敲除动物中靶向输注LIF刺激肌肉再生，但在突变动物中观察到的刺激比对照动物大得多。相比之下，白细胞介素-6和转化生长因子-α也在体外刺激成肌细胞增殖，对再生没有影响。这些发现直接表明LIF参与损伤肌肉的再生，并指出LIF作为治疗剂在神经肌肉疾病的治疗中的用途。John Wiley & Sons，Inc.肌肉神经20：815-822，1997
Although a number of cytokines have been implicated in tissue regeneration, it is unknown which ones actually function in vivo. Here, we use mice with a targeted mutation in the leukemia inhibitory factor (LIF) gene to examine the role of LIF in muscle regeneration. Using a muscle crush model, we show that muscle regeneration in LIF knockout mice is significantly reduced compared to control littermates. Further, targeted infusion of LIF in both normal and LIF knockout animals stimulated muscle regeneration, but the stimulation observed was much greater in the mutant animals than in controls. In contrast, interleukin‐6 and transforming growth factor‐α, which also stimulate myoblast proliferation in vitro, had no effect on regeneration. These findings demonstrate directly that LIF is involved in regeneration of injured muscle and points to the use of LIF as a therapeutic agent in the treatment of neuromuscular disease. © 1997 John Wiley & Sons, Inc. Muscle Nerve 20: 815–822, 1997
无牙（骨质疏松）大鼠长骨中生长激素受体表达减少，并通过集落刺激因子 1 治疗恢复。
DOI：
10.3109/08977199609034562
发表时间：
1996
期刊：
Growth factors (Chur, Switzerland)
影响因子：
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作者：
Symons,AL;MacKay,CA;Leong,K;Hume,DA;Waters,MJ;MarksJr,SC
通讯作者：
MarksJr,SC