"Click-fluors": Modular fluorescent saccharide sensors based on a 1,2,3-triazole ring
"Click-fluors": Modular fluorescent saccharide sensors based on a 1,2,3-triazole ring
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DOI：
10.1021/jo702584u
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发表时间：
2008-04-04
影响因子：
3.6
通讯作者：
James, Tony D.
中科院分区：
文献类型：
--
作者：
Scrafton, David K.;Taylor, James E.;James, Tony D.
报道了一种碳水化合物传感“点击荧光”，它显示出与样品的非典型结合偏好。荧光传感器是由于三唑形成（点击反应）而产生的，而不是简单地通过三唑键将传感器和报告单元结合在一起，并且广泛的容易获得的乙炔单元的潜在适用性意味着用于开发用于快速筛选靶分子的模块化荧光传感器阵列的简单策略将是可用的。
A carbohydrate sensing "click-fluor" is reported which displays a nontypical binding preference with sample saccharides. That a fluorescent sensor is generated as a result of triazole formation (click reaction), rather than simply bringing the sensor and reporter units together via a triazole linkage, and the potential applicability of the wide range of easily accessible acetylene units means a simple strategy for the development of modular fluorescent sensor arrays for rapid screening of target saccharides will be available.