Stroke assessment with intravoxel incoherent motion diffusion-weighted MRI
Stroke assessment with intravoxel incoherent motion diffusion-weighted MRI
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DOI：
10.1002/nbm.3467
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发表时间：
2016-03-01
影响因子：
2.9
通讯作者：
Xu, Jianrong
中科院分区：
文献类型：
--
作者：
Suo, Shiteng;Cao, Mengqiu;Xu, Jianrong
体素内非相干运动（IVIM）弥散加权MRI可以以无创的方式同时测量弥散和灌注特征。本研究旨在确定IVIM在临床脑卒中的脑扩散和灌注特性表征中的潜在效用。对101例急性/亚急性缺血性脑卒中患者的多b值弥散加权图像进行回顾性分析。将高b值增加的扩散数据拟合到简单的单指数模型中，得到表征水表观扩散系数的扩散系数D。采用双指数模型计算ivim衍生的灌注参数：伪扩散系数D*、血管体积分数f和血流相关参数fD*。此外，根据单指数模型，采用全b值拟合表观扩散系数（ADC）。测量每位患者的缺血性病变和对侧正常区域的弥散参数。统计学分析采用配对学生t检验和Pearson相关检验。缺血性病变和对侧正常区弥散数据均服从IVIM双指数行为，且IVIM模型拟合优度优于单指数模型，且赤池信息准则值较低。配对学生t检验显示，所有扩散参数(均P
Intravoxel incoherent motion (IVIM) diffusion-weighted MRI can simultaneously measure diffusion and perfusion characteristics in a non-invasive way. This study aimed to determine the potential utility of IVIM in characterizing brain diffusion and perfusion properties for clinical stroke. The multi-b-value diffusion-weighted images of 101 patients diagnosed with acute/subacute ischemic stroke were retrospectively evaluated. The diffusion coefficient D, representing the water apparent diffusivity, was obtained by fitting the diffusion data with increasing high b-values to a simple mono-exponential model. The IVIM-derived perfusion parameters, pseudodiffusion coefficient D*, vascular volume fraction f and blood flow-related parameter fD*, were calculated with the bi-exponential model. Additionally, the apparent diffusion coefficient (ADC) was fitted according to the mono-exponential model using all b-values. The diffusion parameters for the ischemic lesion and normal contralateral region were measured in each patient. Statistical analysis was performed using the paired Student t-test and Pearson correlation test. Diffusion data in both the ischemic lesion and normal contralateral region followed the IVIM bi-exponential behavior, and the IVIM model showed better goodness of fit than the mono-exponential model with lower Akaike information criterion values. The paired Student t-test revealed significant differences for all diffusion parameters (all P