The chemotherapeutic response of a murine (VM) model of human glioma.
The chemotherapeutic response of a murine (VM) model of human glioma.
复制标题
人神经胶质瘤的鼠（VM）模型的化学治疗反应。
DOI：
10.1038/bjc.1990.10
复制
发表时间：
1990-01
影响因子：
8.8
通讯作者：
Thomas, D G
中科院分区：
文献类型：
--
作者：
Bradford, R;Darling, J L;Thomas, D G
利用来源于VM自发性小鼠星形细胞瘤的细胞系，已经开发了可靠的人恶性胶质瘤的体外-体内模型。在本文中，我们研究了具有已知活性的细胞毒性药物对其他动物脑肿瘤模型和人体疾病在体内VM模型上的影响。药物BCNU、CCNU和长春新碱在同基因动物皮下生长的肿瘤中产生显著的体积减小。丙卡巴肼无效。同样，BCNU，CCNU和长春新碱产生小，但统计学上显着增加VM小鼠的存活率，脑内肿瘤，但甲基苄肼再次无效。VM模型对亚硝基脲的适度但显著的反应比先前描述的动物模型更接近地模拟人类情况。
Using a cell line derived from the VM spontaneous murine astrocytoma, a reliable in vitro-in vivo model of human malignant glioma has been developed. In this paper we examine the effects of cytotoxic drugs with known activity against other animal brain tumour models and human disease on the in vivo VM model. The drugs BCNU, CCNU and vincristine produced significant volume reduction in tumours growing at a subcutaneous location in syngeneic animals. Procarbazine was ineffective. Similarly, BCNU, CCNU and vincristine produced small but statistically significant increases in survival of VM mice bearing the intracerebral tumour, but procarbazine was again ineffective. The modest, but significant, response of the VM model to the nitrosoureas mimics the human situation more closely than previously described animal models.