EGFL7 meets miRNA-126: an angiogenesis alliance.
EGFL7 meets miRNA-126: an angiogenesis alliance.
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DOI：
10.1186/2040-2384-2-9
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发表时间：
2010-06-08
期刊：
影响因子：
--
通讯作者：
Schmidt MHH
中科院分区：
文献类型：
--
作者：
Nikolic I;Plate KH;Schmidt MHH
血管通过严格调控的血管发生和血管生成程序从头形成。这两个过程是不同的，但它们共享的步骤之一是形成中央腔，当组织为血管索的细胞群经历复杂的变化以实现管状形态时。最近，被称为表皮生长因子样结构域7（EGFL 7）的蛋白质被描述为一种新的内皮细胞衍生因子，参与调节血管组装过程中细胞的空间排列。EGFL 7对肾小管形成和血管形状有影响，因此加入了控制血管形成的大分子家族。直到最近，EGFL 7作用的分子机制才开始阐明，细胞外基质（ECM）的形成以及Notch信号传导可能在介导其生物学效应中发挥作用。此外，在敲除动物模型中的发现表明miR-126（位于egfl 7基因内的miRNA）通过促进VEGF信号传导、血管生成和血管完整性在血管发育中具有主要作用。本文综述了我们目前对EGFL 7和miR-126的了解，并将讨论这两种生物活性分子对血管形成的影响。
Blood vessels form de novo through the tightly regulated programs of vasculogenesis and angiogenesis. Both processes are distinct but one of the steps they share is the formation of a central lumen, when groups of cells organized as vascular cords undergo complex changes to achieve a tube-like morphology. Recently, a protein termed epidermal growth factor-like domain 7 (EGFL7) was described as a novel endothelial cell-derived factor involved in the regulation of the spatial arrangement of cells during vascular tube assembly. With its impact on tubulogenesis and vessel shape EGFL7 joined the large family of molecules governing blood vessel formation. Only recently, the molecular mechanisms underlying EGFL7's effects have been started to be elucidated and shaping of the extracellular matrix (ECM) as well as Notch signaling might very well play a role in mediating its biological effects. Further, findings in knock-out animal models suggest miR-126, a miRNA located within the egfl7 gene, has a major role in vessel development by promoting VEGF signaling, angiogenesis and vascular integrity. This review summarizes our current knowledge on EGFL7 and miR-126 and we will discuss the implications of both bioactive molecules for the formation of blood vessels.