Surface modification of Y2O3 nanoparticles
Surface modification of Y2O3 nanoparticles
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DOI：
10.1021/la701653v
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发表时间：
2007-08-28
期刊：
影响因子：
3.9
通讯作者：
Schwartz, Jeffrey
中科院分区：
文献类型：
--
作者：
Traina, Christopher A.;Schwartz, Jeffrey
稀土离子掺杂的氧化钇（Y2O3）纳米晶体无毒，可以制备为细胞成像的上转换材料，但它们不能很好地悬浮在水中。与溶解在酸性介质中的趋势相反，氧化钇 (Y2O3) 纳米颗粒很容易与膦酸反应，生成膦酸盐键合的氧化钇颗粒。通过选择膦酸，可以控制纳米颗粒的亲水性。描述了新型四甘醇衍生膦酸的合成；用相应的膦酸盐处理的氧化钇很容易分散在水介质中。还描述了与可用于与生物分子交叉偶联的膦酸酯键合的氧化钇的制备。
Rare earth ion-doped yttrium oxide (Y2O3) nanocrystals are nontoxic and can be prepared as upconversion materials for cellular imaging, but they do not suspend well in water. In contrast to their tendency to dissolve in acidic media, yttria (Y2O3) nanoparticles readily react with phosphonic acids to give phosphonate-bonded yttria particles. Through the choice of phosphonic acid, the hydrophilicity of the nanoparticles can be controlled. The synthesis of a novel tetraethylene glycol-derived phosphonic acid is described; yttria treated with the corresponding phosphonate is easily dispersed in aqueous media. The preparation of yttria bonded to a phosphonate that may be used for cross coupling with biomolecules is also described.