Smoking Behavior and Lung Cancer in a Biracial Cohort The Atherosclerosis Risk in Communities Study
Smoking Behavior and Lung Cancer in a Biracial Cohort The Atherosclerosis Risk in Communities Study
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DOI：
10.1016/j.amepre.2014.01.017
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发表时间：
2014-06-01
影响因子：
5.5
通讯作者：
Huxley, Rachel R.
中科院分区：
文献类型：
--
作者：
Prizment, Anna E.;Yatsuya, Hiroshi;Huxley, Rachel R.
背景：在美国，肺癌的发病率因种族而异，黑人男子的发病率最高。黑人和白人在吸烟行为上存在显著差异，但关于这些差异如何导致肺癌的种族差异知之甚少。目的：在前瞻性队列社区动脉粥样硬化风险研究中，比较14，610名黑人和白人与吸烟相关的肺癌风险。方法：在1990-1992年、1993-1995年和1996-1998年的基线和三次随访中确定了吸烟特征（回复率分别为93%、86%和80%），以及年度电话访谈。2012年秋季对数据进行了分析。多变量调整比例风险模型被用来计算肺癌的风险比和95%CIs.Results：超过20年的随访（1987-2006），470例肺癌发生。黑人男性肺癌发病率最高，黑人女性最低。然而，没有证据支持吸烟状态、强度或开始吸烟时的年龄与肺癌风险之间存在种族差异（所有p（相互作用）>= 0.25）。22岁时开始吸烟者的风险比为3.03（95% CI =1.62，5.67）。长期戒烟（>= 10年）与肺癌风险降低相关，白人和黑人的获益相当，分别为84%和74%（P-交互作用=0.25）。(C)2014年美国预防医学杂志
Background: In the U.S., the incidence of lung cancer varies by race, with rates being highest among black men. There are marked differences in smoking behavior between blacks and whites, but little is known regarding how these differences contribute to the racial disparities in lung cancer.Purpose: To compare the lung cancer risk associated with smoking in 14,610 blacks and whites in the prospective cohort Atherosclerosis Risk in Communities study.Methods: Smoking characteristics were ascertained at baseline and three follow-up visits in 1990-1992, 1993-1995, and 1996-1998 (response rates were 93%, 86%, and 80%, respectively), as well as from annual telephone interviews. Data Were analyzed in the fall of 2012. Multivariable-adjusted proportional hazards models were used to calculate hazard ratios and 95% CIs for lung cancer.Results: Over 20 years of follow-up (1987-2006), 470 incident cases of lung cancer occurred. Lung cancer incident rates were highest in black men and lowest in black women. However, there was no evidence to support racial differences in the associations of smoking status, intensity, or age at initiation with lung cancer risk (all p(interaction) >= 0.25). The hazard ratio for those who started smoking at age 22 years was 3.03 (95% CI =1.62, 5.67). Prolonged smoking cessation ( >= 10 years) was associated with a decrease in lung cancer risk, with equivalent benefits in whites and blacks, 84% and 74%, respectively (P-interaction=0.25).Conclusions: Smoking confers similar lung cancer risk in blacks and whites. (C) 2014 American Journal of Preventive Medicine