Regulation of drug intake
Regulation of drug intake
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DOI：
10.1037//1064-1297.9.2.131
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发表时间：
2001-05-01
影响因子：
2.3
通讯作者：
Carroll, ME
中科院分区：
文献类型：
--
作者：
Lynch, WJ;Carroll, ME
药物摄入的调节是指在特定的时间段内维持相对恒定的药物水平。了解药物摄入的调节对于确定药物如何作为强化剂以及如何改变其强化作用至关重要。然而，人们对药物摄入的调节知之甚少，对其背后的机制也知之甚少。讨论了提议解释药物摄入调节结果的三种机制，以确定它们与药物强化反应的相关性。这些机制包括厌恶效应、直接效应和饱足感。尽管本次综述支持饱腹感发挥更大的作用，但药物产生饱腹感的程度可能会有所不同，并且饱足感是否与药物的厌恶作用或直接作用相一致尚不清楚。
Regulation of drug intake refers to the maintenance of relatively constant levels of drug over a specified time period. An understanding of regulation of drug intake may be critical in determining how drugs function as reinforcers and how their reinforcing effects may be modified. However, little is known about regulation of drug intake, and the mechanisms underlying it are poorly understood. Three mechanisms that have proposed to account for findings of regulation of drug intake were discussed to determine their relevance for drug-reinforced responding. These mechanisms include aversive effects, direct effects, and satiation. Although a greater role for satiation was supported in this review, drugs may vary on the degree to which they can produce satiation and whether satiation acts in concert with either the aversive effects or the direct effects of drugs is unclear.