Changes in Human Milk Immunoglobulin Profile During Prolonged Lactation
Changes in Human Milk Immunoglobulin Profile During Prolonged Lactation
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DOI：
10.3389/fped.2020.00428
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发表时间：
2020-08-07
影响因子：
2.6
通讯作者：
Orczyk-Pawilowicz, Magdalena
中科院分区：
文献类型：
--
作者：
Czosnykowska-Lukacka, Matylda;Lis-Kuberka, Jolanta;Orczyk-Pawilowicz, Magdalena
母乳喂养期间输送给婴儿的母乳免疫球蛋白 (Igs) 对于塑造和调节未成熟婴儿的免疫系统至关重要，并提供针对病原体的有效保护。该研究的目的是使用 ELISA 方法评估 116 名哺乳期母亲在第 1 个月至第 48 个月的长期哺乳期间乳汁中的免疫球蛋白浓度。从第 1 个月到第 48 个月，蛋白质 SIgA 和 IgG（而非 IgM）浓度与哺乳期呈正相关（分别为 r= 0.69，p < 0.005；r= 0.54，p < 0.05；andr= 0.27，p < 0.05）。 SIgA 和 IgG 的浓度在第一年最低（分别为 2.12 +/- 0.62 g/L 和 14.71 +/- 6.18 mg/L），在哺乳期第二年后观察到最高浓度（分别为 7.55 +/- 7.16 g/L 和 18.95 +/- 6.76 mg/L）。 IgM 浓度在 2 年内保持稳定（2.81 +/- 2.74 mg/L），但 24 个月后升高（3.82 +/- 3.05 mg/L），但不显着。此外，蛋白质（r=-0.24，p<0.05）和SIgA（r=-0.47，p<0.05）浓度与喂养次数呈负相关。哺乳期第二年后的母乳中蛋白质、SIgA 和 IgG 的浓度显着升高。即使在引入固体食物后，长时间哺乳期间的高浓度免疫球蛋白和蛋白质也是支持母乳喂养的另一个论点，并且应该成为保护儿童健康的首要目标之一。
Mother's milk immunoglobulins (Igs) delivered to infants during breastfeeding are crucial in shaping and modulating immature infants' immune system and provide efficient protection against pathogens. The aim of the study was to evaluate the immunoglobulin concentrations in milk of 116 lactating mothers over prolonged lactation from the 1st to the 48th month using the ELISA method. The concentration of proteins, SIgA and IgG, but not IgM, showed a positive correlation (r= 0.69,p< 0.005;r= 0.54,p< 0.05; andr= 0.27,p< 0.05, respectively) with lactation from the 1st to the 48th month. The lowest concentrations of SIgA and IgG were observed for the first year (2.12 +/- 0.62 g/L and 14.71 +/- 6.18 mg/L, respectively) and the highest after the 2nd year of lactation (7.55 +/- 7.16 g/L and 18.95 +/- 6.76 mg/L, respectively). The IgM concentration remained stable during 2 years (2.81 +/- 2.74 mg/L), but after 24 months it was higher (3.82 +/- 3.05 mg/L), although not significantly. Moreover, negative correlations of protein (r= -0.24,p< 0.05) and SIgA (r= -0.47,p< 0.05) concentrations with the number of feedings were found. Human milk after the 2nd year of lactation contains significantly higher concentrations of protein, SIgA, and IgG. High concentration of immunoglobulins and protein during prolonged lactation is an additional argument to support breastfeeding even after introducing solid foods and should be one of the overarching goals in the protection of children's health.