Resistance integrons: class 1, 2 and 3 integrons.
Resistance integrons: class 1, 2 and 3 integrons.
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DOI：
10.1186/s12941-015-0100-6
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发表时间：
2015-10-20
影响因子：
5.7
通讯作者：
Yu G
中科院分区：
文献类型：
--
作者：
Deng Y;Bao X;Ji L;Chen L;Liu J;Miao J;Chen D;Bian H;Li Y;Yu G
近年来，由于临床和兽医治疗中滥用现有抗生素，导致微生物中抗生素耐药性的扩散，给未来此类细菌感染的治疗带来了困境，抗菌素耐药性已被认为是当前全球公共卫生的主要问题之一，并据报道已广泛传播并扩展到多种微生物。中国作为目前抗生素滥用最严重的地区之一，每年人均抗生素处方量（包括临床和兽医治疗）已接近140克，粗略估计是英国的10倍，被认为是“超级细菌”出现的潜在地区。基于过去十年中国广州市的整合子监测，本综述旨在从临床环境和环境角度总结整合子的作用，重点关注1、2、3类整合子的发生和流行情况。
As recently indiscriminate abuse of existing antibiotics in both clinical and veterinary treatment leads to proliferation of antibiotic resistance in microbes and poses a dilemma for the future treatment of such bacterial infection, antimicrobial resistance has been considered to be one of the currently leading concerns in global public health, and reported to widely spread and extended to a large variety of microorganisms. In China, as one of the currently worst areas for antibiotics abuse, the annual prescription of antibiotics, including both clinical and veterinary treatment, has approaching 140 gram per person and been roughly estimated to be 10 times higher than that in the United Kingdom, which is considered to be a potential area for the emergence of “Super Bugs”. Based on the integrons surveillance in Guangzhou, China in the past decade, this review thus aimed at summarizing the role of integrons in the perspective of both clinical setting and environment, with the focus on the occurrence and prevalence of class 1, 2 and 3 integrons.