DIFFERENT LY ANTIGEN PHENOTYPES OF INVITRO INDUCED HELPER AND SUPPRESSOR CELLS
DIFFERENT LY ANTIGEN PHENOTYPES OF INVITRO INDUCED HELPER AND SUPPRESSOR CELLS
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DOI：
10.1038/258614a0
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发表时间：
1975-01-01
期刊：
影响因子：
64.8
通讯作者：
KONTIAINEN, S
中科院分区：
文献类型：
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作者：
FELDMAN, M;BEVERLEY, PCL;KONTIAINEN, S
胸腺来源的(T)细胞在免疫系统中起着重要作用。它们介导多种功能，如T-B协作(辅助细胞)1和混合淋巴细胞反应2，成为杀伤细胞3，在移植物宿主反应中活跃(见参考文献3)。4)发挥抑制细胞的作用。通过使用针对T细胞特异性同种异体抗原Thy-1的抗血清，有助于将负责这些功能的细胞鉴定为T细胞。6)(以前称为θ)。据报道，Ly同种抗原仅存在于T细胞7上，识别功能不同的T细胞亚群8。例如，T辅助细胞可被抗Ly-1裂解，但不能被抗Ly-2裂解，因此其表型为Ly-1+2−，而T杀伤细胞是一个不同的亚群，为Ly-1−2+。我们在此报道，在体外诱导的T抑制细胞具有不同的Ly同种异体抗原表型，而在体外诱导的T辅助细胞来自相同的脾细胞池。
THYMUS-derived (T) cells have a major role in immune systems. They mediate various functions, such as T–B cooperation (‘helper cells’)1and the mixed lymphocyte reaction2, become killer cells3, are active in graftversushost responses (reviewed in ref. 4) and act as suppressor cells5. The identification of the cells responsible for these functions as T cells was facilitated by the use of antisera against the T-cell-specific alloantigen, Thy-1 (ref. 6) (formerly known asθ). It has been reported that Ly allo-antigens, present exclusively on T cells7, identify functionally distinct subpopulations of T cells8. For example, T helper cells were lysed by anti-Ly–1, but not by anti-Ly–2, so that their phenotype is Ly–1+2−, whereas T killer cells were a distinct subpopulation, being Ly–1−2+. We report here that specific T suppressor cells inducedin vitrohave a different Ly alloantigen phenotype from T helper cells inducedin vitrofrom the same spleen cell pool.