Diurnal variation of corneal and corneal epithelial thickness measured using optical coherence tomography
Diurnal variation of corneal and corneal epithelial thickness measured using optical coherence tomography
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DOI：
10.1097/00003226-200107000-00008
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发表时间：
2001-07-01
期刊：
影响因子：
2.8
通讯作者：
Simpson, TL
中科院分区：
文献类型：
--
作者：
Feng, YW;Varikooty, J;Simpson, TL
确定光学相干断层扫描（OCT）测量过夜角膜肿胀和去肿胀的可行性，特别是检查角膜上皮的过夜变化和白天的恢复情况。方法.招募10名健康志愿者。在10：00 PM（基线）、8：30 AM以及此后每2小时进行一次角膜OCT成像，直至4：30 PM。将右眼或左眼用胶带封闭（使用纱布垫和手术胶带），直至第二天上午8：30。沿以视轴为中心的1 mm条带沿着进行测量。结果在基线时，对照眼和实验眼之间的角膜或上皮厚度没有差异（所有p > 0.05）。在揭除贴片后即刻，贴片眼的角膜和上皮厚度高于基线（均p < 0.05）。术后1个月角膜和角膜上皮肿胀率分别为5.5%和8.1%（P > 0.05）。术后2h，实验眼角膜上皮厚度恢复至术前水平（p > 0.05），但角膜厚度直到术后4h才恢复至术前水平。对于对照眼，与基线相比没有差异（所有p > 0.05）。结论角膜和角膜上皮均经历成比例的相似量的过夜肿胀。角膜的过夜肿胀恢复可能比上皮慢。OCT提供了有关眼前节形态测量的有价值的信息。
To determine the feasibility of optical coherence tomography (OCT) measurement of overnight corneal swelling and deswelling and, specifically, to examine overnight changes in the corneal epithelium and recovery during the day. Methods. Ten healthy volunteers were recruited. Corneal OCT imaging was performed at 10:00 PM (baseline), 8:30 AM, and every 2 hours thereafter until 4:30 PM. Either the right or left eye was taped shut (using a gauze pad and surgical tape) until the 8:30 AM session of the next day. Measurements were made along a l-mm strip centered on the visual axis. Results. At baseline, there were no differences in corneal or epithelial thickness between control and experimental eyes (all p > 0.05). Immediately after patch removal, corneal and epithelial thicknesses of patched eyes were higher than the baseline (all p < 0.05). In patched eyes, the cornea and epi thelium swelled 5.5% and 8.1% overnight, respectively (p > 0.05). Two hours later, the epithelial thickness of the experimental eyes recovered to baseline level (p > 0.05), but corneal thickness did not reach to baseline level until 4 hours after patch removal. For control eyes, there were no differences compared with baseline (all p > 0.05). Conclusion. Both cornea and corneal epithelium experience proportionately similar amounts of overnight swelling. Recovery of overnight swelling may be slower for the cornea than for the epithelium. OCT provides valuable information about anterior segment morphometry.